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Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition

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Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition

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dc.contributor.author Lull Noguera, Nuria es_ES
dc.contributor.author Noé, Enrique es_ES
dc.contributor.author Lull Noguera, Juan José es_ES
dc.contributor.author García Panach, Javier es_ES
dc.contributor.author Chirivella, Javier es_ES
dc.contributor.author Ferri, Joan es_ES
dc.contributor.author López-Aznar, Diego es_ES
dc.contributor.author Sopena, Pablo es_ES
dc.contributor.author Robles Viejo, Montserrat es_ES
dc.date.accessioned 2015-06-03T11:43:07Z
dc.date.available 2015-06-03T11:43:07Z
dc.date.issued 2010
dc.identifier.issn 0269-9052
dc.identifier.uri http://hdl.handle.net/10251/51213
dc.description.abstract Objective: To study the relationship between thalamic glucose metabolism and neurological outcome after severe traumatic brain injury (TBI). Methods: Forty-nine patients with severe and closed TBI and 10 healthy control subjects with 18F-FDG PET were studied. Patients were divided into three groups: MCS&VS group (n ¼ 17), patients in a vegetative or a minimally conscious state; In-PTA group (n ¼ 12), patients in a state of post-traumatic amnesia (PTA); and Out-PTA group (n ¼ 20), patients who had emerged from PTA. SPM5 software implemented in MATLAB 7 was used to determine the quantitative differences between patients and controls. FDG-PET images were spatially normalized and an automated thalamic ROI mask was generated. Group differences were analysed with two sample voxel-wise t-tests. Results: Thalamic hypometabolism was the most prominent in patients with low consciousness (MCS&VS group) and the thalamic hypometabolism in the In-PTA group was more prominent than that in the Out-PTA group. Healthy control subjects showed the greatest thalamic metabolism. These differences in metabolism were more pronounced in the internal regions of the thalamus. Conclusions: The results confirm the vulnerability of the thalamus to suffer the effect of the dynamic forces generated during a TBI. Patients with thalamic hypometabolism could represent a sub-set of subjects that are highly vulnerable to neurological disability after TBI. es_ES
dc.language Inglés es_ES
dc.publisher Informa Healthcare es_ES
dc.relation.ispartof Brain Injury es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Voxel-based analysis es_ES
dc.subject Positron emission tomography es_ES
dc.subject Consciousness, es_ES
dc.subject PET-FDG es_ES
dc.subject Prognosis es_ES
dc.subject Thalamus es_ES
dc.subject Traumatic brain injury es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3109/02699052.2010.494592
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Aplicaciones de las Tecnologías de la Información - Institut Universitari d'Aplicacions de les Tecnologies de la Informació es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Lull Noguera, N.; Noé, E.; Lull Noguera, JJ.; Garcia Panach, J.; Chirivella, J.; Ferri, J.; López-Aznar, D.... (2010). Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition. Brain Injury. 24(9):1098-1107. doi:10.3109/02699052.2010.494592 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.3109/02699052.2010.494592 es_ES
dc.description.upvformatpinicio 1098 es_ES
dc.description.upvformatpfin 1107 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 39432
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