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Multifunctional hybrid materials for combined photo and chemotherapyof cancer

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Multifunctional hybrid materials for combined photo and chemotherapyof cancer

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dc.contributor.author Botella Asuncion, Pablo es_ES
dc.contributor.author Ortega, Ilida es_ES
dc.contributor.author Quesada Vilar, Manuel es_ES
dc.contributor.author Madrigal Madrigal, Roque Fernando es_ES
dc.contributor.author Muniesa Lajara, Carlos es_ES
dc.contributor.author Fimia Gil, Antonio es_ES
dc.contributor.author Fernandez Jover, Eduardo es_ES
dc.contributor.author Corma Canós, Avelino es_ES
dc.date.accessioned 2015-06-16T10:17:38Z
dc.date.issued 2012
dc.identifier.issn 1477-9226
dc.identifier.uri http://hdl.handle.net/10251/51767
dc.description.abstract [EN] Combined chemo and photothermal therapy in in vitro testing has been achieved by means of multifunctional nanoparticles formed by plasmonic gold nanoclusters with a protecting shell of porous silica that contains an antitumor drug. We propose a therapeutic nanoplatform that associates the optical activity of small gold nanoparticles aggregates with the cytotoxic activity of 20(S)-camptothecin simultaneously released for the efficient destruction of cancer cells. For this purpose, a method was used for the controlled assembly of gold nanoparticles into stable clusters with a tailored absorption crosssection in the vis/NIR spectrum, which involves aggregation in alkaline medium of 15 nm diameter gold colloids protected with a thin silica layer. Clusters were further encapsulated in an ordered homogeneous mesoporous silica coating that provides biocompatibility and stability in physiological fluids. After internalization in 42-MG-BA human glioma cells, these protected gold nanoclusters were able to produce effective photothermolysis under femtosecond pulse laser irradiation of 790 nm. Cell death occurred by combination of a thermal mechanism and mechanical disruption of the membrane cell due to induced generation of micrometer-scale bubbles by vaporizing the water inside the channels of the mesoporous silica coating. Moreover, the incorporation of 20(S)-camptothecin within the pores of the external shell, which was released during the process, provoked significant cell death increase. This therapeutic model could be of interest for application in the treatment and suppression of non-solid tumors. es_ES
dc.description.sponsorship This work was financially supported by Comision Interministerial de Ciencia y Tecnologia of Spain through the projects FIS2006-09319, SAF2008-03694, MAT2006-14274-C02-01 and MULTICAT (Consolider-Ingenio 2010). CM thanks the Spanish "Ministerio de Economia y Competitividad" for a FDU Ph D studentship (AP2008-02851).
dc.language Inglés es_ES
dc.publisher Royal Society of Chemistry es_ES
dc.relation.ispartof Dalton Transactions es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Absorption cross-section es_ES
dc.subject Alkaline medium es_ES
dc.subject Antitumor drugs es_ES
dc.subject Camptothecin (CPT) es_ES
dc.subject Cancer cells es_ES
dc.subject Controlled assembly es_ES
dc.subject Cytotoxic activities es_ES
dc.subject Femtosecond pulse laser es_ES
dc.subject Glioma cells es_ES
dc.subject Gold nanocluster es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Multifunctional hybrid materials for combined photo and chemotherapyof cancer es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1039/c2dt30381g
dc.relation.projectID info:eu-repo/grantAgreement/MEC//FIS2006-09319/ES/ESTUDIO DE MATERIALES DE REGISTRO HOLOGRAFICO CON PULSOS DE FEMTOSEGUNDO: APLICACIONES AL ALMACENAMIENTO OPTICO DE INFORMACION/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//SAF2008-03694/ES/NUEVOS DISPOSITIVOS DE REHABILITACION VISUAL/
dc.relation.projectID info:eu-repo/grantAgreement/MEC//MAT2006-14274-C02-01/ES/DISEÑO MOLECULAR DE NANOMATERIALES ESTRUCTURADOS ORGANICOS-INORGANICOS PARA SU APLICACION EN CATALISIS, SEPARACION DE GASES Y BIOMEDICA./
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AP2008-02851/ES/AP2008-02851/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Botella Asuncion, P.; Ortega, I.; Quesada Vilar, M.; Madrigal Madrigal, RF.; Muniesa Lajara, C.; Fimia Gil, A.; Fernandez Jover, E.... (2012). Multifunctional hybrid materials for combined photo and chemotherapyof cancer. Dalton Transactions. 41(31):9243-9554. https://doi.org/10.1039/c2dt30381g es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1039/c2dt30381g es_ES
dc.description.upvformatpinicio 9243 es_ES
dc.description.upvformatpfin 9554 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 41 es_ES
dc.description.issue 31 es_ES
dc.relation.senia 245068
dc.identifier.pmid 22555652
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder Ministerio de Educación y Ciencia es_ES


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