Dias, JC.; Ribeiro, C.; Sencadas, V.; Botelho, G.; Gómez Ribelles, JL.; Lanceros Mendez, S. (2012). Influence of fiber diameter and crystallinity on the stability of electrospun poly(L-lactic acid) membranes to hydrolytic degradation. Polymer Testing. 31(6):770-776. doi:10.1016/j.polymertesting.2012.05.007
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/52497
Title:
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Influence of fiber diameter and crystallinity on the stability of electrospun poly(L-lactic acid) membranes to hydrolytic degradation
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Author:
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Dias, Juliana C.
Ribeiro, Clarisse
Sencadas, V.
Botelho, G.
Gómez Ribelles, José Luís
Lanceros Mendez, Senentxu
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UPV Unit:
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Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular
Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada
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Issued date:
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Abstract:
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Hydrolytic degradation of electrospun mats of poly(l-lactic acid), PLLA, as a function of crystallinity and fiber diameter has been studied. The degradation in a saline phosphate buffer solution (PBS) up to 20 weeks produced ...[+]
Hydrolytic degradation of electrospun mats of poly(l-lactic acid), PLLA, as a function of crystallinity and fiber diameter has been studied. The degradation in a saline phosphate buffer solution (PBS) up to 20 weeks produced a slight decrease in the sample mass but a clear decrease of the polymer average molecular weight in the amorphous fibers. This effect decreases as crystallinity increases. It is important for applications that morphological characteristics of the membranes such as average fiber diameter and membrane porosity are also affected by the degradation process. Fiber diameter increases while membrane porosity decreases, resulting in closer packed fibers due to the release of internal tensions related to the electrospinning and/or thermal treatment processes.
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Subjects:
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Poly (l-lactic acid)
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Electrospun nanofibers
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In-vitro degradation
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Viscosity average molecular weight
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Copyrigths:
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Cerrado |
Source:
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Polymer Testing. (issn:
0142-9418
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DOI:
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10.1016/j.polymertesting.2012.05.007
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Publisher:
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Elsevier
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Publisher version:
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http://dx.doi.org/10.1016/j.polymertesting.2012.05.007
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Project ID:
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info:eu-repo/grantAgreement/MICINN//MAT2010-21611-C03-01/ES/MATERIALES BIOESTABLES Y BIOREABSORBIBLES A LARGO PLAZO COMO SOPORTES MACROPOROSOS PARA LA REGENERACION DEL CARTILAGO ARTICULAR/
...[+]
info:eu-repo/grantAgreement/MICINN//MAT2010-21611-C03-01/ES/MATERIALES BIOESTABLES Y BIOREABSORBIBLES A LARGO PLAZO COMO SOPORTES MACROPOROSOS PARA LA REGENERACION DEL CARTILAGO ARTICULAR/
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63148%2F2009/PT/ELECTROACTIVE MATERIALS BASED POROUS MEMBRANES AND SCAFFOLDS FOR BIOMEDICAL APPLICATIONS/
info:eu-repo/grantAgreement//COST Action MP1003/EU/European Scientific Network for Artificial Muscles/ESNAM/
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/109368/PT/“Smart joint implants using bionanocomposites-(SIMBIO)”/
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/69316/PT/Multiferroic, magnetoelectric and metallic micro and nanocomposites based on electroactive polymers for advanced applications/
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/73030/PT/Polarization-driven self-assembly of organic and biomaterials using ferroelectric polymers/
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Thanks:
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This work is funded by FEDER funds through the "Programa Operacional Factores de Competitividade - COMPETE" and by national funds arranged by FCT - Fundacao para a Ciencia e a Tecnologia, project references NANO/NMed-SD/0156/2007, ...[+]
This work is funded by FEDER funds through the "Programa Operacional Factores de Competitividade - COMPETE" and by national funds arranged by FCT - Fundacao para a Ciencia e a Tecnologia, project references NANO/NMed-SD/0156/2007, PTDC/CTM/73030/2006 and PTDC/CTM/69316/2006. The authors also thank support from the COST Action MP1003, 2010 'European Scientific Network for Artificial Muscles'. V.S. thanks the FCT for the SFRH/BPD/63148/2009 grant. C. R. thanks the Iberian Institute of Nanotechnology Laboratory (IINL) for a PhD grant. JLGR acknowledge the support of the Spanish Ministry of Education through project No. MAT2010-21611-C03-01 (including the FEDER financial support).
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Type:
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Artículo
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