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dc.contributor.author | Torres-Cartas, Sagrario | es_ES |
dc.contributor.author | Martín-Biosca, Y. | es_ES |
dc.contributor.author | Villanueva-Camañas, R. M. | es_ES |
dc.contributor.author | Sagrado, S. | es_ES |
dc.contributor.author | Medina-Hernández, M. J. | es_ES |
dc.date.accessioned | 2015-09-17T14:11:17Z | |
dc.date.available | 2015-09-17T14:11:17Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | http://hdl.handle.net/10251/54765 | |
dc.description.abstract | [EN] Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability. | es_ES |
dc.description.sponsorship | The authors acknowledge the Spanish Ministry of Science and Technology (MCYT) and the European Regional Development Fund (ERDF) for the financial support (Project SA2005-01435). | |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | European Journal of Medicinal Chemistry | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Mutagenicity | es_ES |
dc.subject | Biopartitioning micellar chromatography | es_ES |
dc.subject | Aromatic amines | es_ES |
dc.subject | Quantitative retentione-activity relationships | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.title | Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.ejmech.2007.02.022 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//SAF2005-01435/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres | es_ES |
dc.description.bibliographicCitation | Torres-Cartas, S.; Martín-Biosca, Y.; Villanueva-Camañas, RM.; Sagrado, S.; Medina-Hernández, MJ. (2007). Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines. European Journal of Medicinal Chemistry. 42(11-12):1396-1402. https://doi.org/10.1016/j.ejmech.2007.02.022 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ejmech.2007.02.022 | es_ES |
dc.description.upvformatpinicio | 1396 | es_ES |
dc.description.upvformatpfin | 1402 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 42 | es_ES |
dc.description.issue | 11-12 | es_ES |
dc.relation.senia | 31414 | |
dc.identifier.pmid | 17482318 | |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |