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dc.contributor.author | Torres-Cartas, Sagrario | es_ES |
dc.contributor.author | Martín-Biosca, Y. | es_ES |
dc.contributor.author | Sagrado, S. | es_ES |
dc.contributor.author | Villanueva-Camañas, R. M. | es_ES |
dc.contributor.author | Medina-Hernández, M. J. | es_ES |
dc.date.accessioned | 2015-09-17T14:20:33Z | |
dc.date.available | 2015-09-17T14:20:33Z | |
dc.date.issued | 2007-01 | |
dc.identifier.issn | 0269-3879 | |
dc.identifier.uri | http://hdl.handle.net/10251/54769 | |
dc.description.abstract | [EN] The determination of highly hydrophobic basic compounds by means of conventional reversed-phase liquid chromatographic methods has several drawbacks. Owing to the characteristics of micellar liquid chromatography (MLC) and capillary electrophoresis (CE), these techniques could be advantageous alternatives to reversed-phase chromatographic methods for the determination of these kinds of compounds. The objective of this study was to develop and compare MLC and CE methods for the determination of antipsychotic basic drugs (amitryptiline, haloperidol, perphenazine and thioridazine) in pharmaceutical preparations. The chromatographic determination of the analytes was performed on a Kromasil C18 analytical column; the mobile phase was 0.04 M cetyltrimethylammonium bromide (CTAB), at pH 3, containing 5% 1-butanol, at a flow rate of 1 mL/min. The CE separation was performed in a fused-silica capillary with a 50 mM tris-(hydroxymethyl)-aminomethane buffer, pH 7, at an applied voltage of 20 kV, using barbital as internal stardard. The proposed methods are suitable for a reliable quantitation of these compounds in the commercial tablets and drops in terms of accuracy and precision and require a very simple pre-treatment of the samples. By comparing the performance characteristics and experimental details of the MLC and CE methods we conclude that CE seems to be slightly better than MLC in the determination of highly hydrophobic compounds in pharmaceuticals in terms of resolution and economy, taking into account that the limits of detection are not a handicap in pharmaceutical samples. Copyright © 2006 John Wiley & Sons, Ltd. | es_ES |
dc.description.sponsorship | The authors acknowledge the Interministerial Commission of Science and Technology (CICYT) of Spain (Project SAF 2005-01435) for financial support. | |
dc.language | Inglés | es_ES |
dc.publisher | Wiley: 12 months | es_ES |
dc.relation.ispartof | Biomedical Chromatography | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Micellar liquid chromatography | es_ES |
dc.subject | Capillary electrophoresis | es_ES |
dc.subject | Antipsychotic drugs | es_ES |
dc.subject | Pharmaceutical analysis | es_ES |
dc.subject | Hydrophobic basic drugs | es_ES |
dc.subject | Cetyltrimethylammonium bromide | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.title | Comparison between micellar liquid chromatography and capillary zone electrophoresis for the determination of hydrophobic basic drugs in pharmaceutical preparations | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/bmc.710 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//SAF2005-01435/ES/DESARROLLO DE MICROSISTEMAS DE SEPARACION DE ALTO RENDIMIENTO PARA LA EVALUACION DE LAS INTERACCIONES NO ESPECIFICAS XENOBIOTICO-BIOMEMBRANA Y ESPECIFICAS XENOBIOTICO QUIRAL-PROTEINA PLASMATICA/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres | es_ES |
dc.description.bibliographicCitation | Torres-Cartas, S.; Martín-Biosca, Y.; Sagrado, S.; Villanueva-Camañas, RM.; Medina-Hernández, MJ. (2007). Comparison between micellar liquid chromatography and capillary zone electrophoresis for the determination of hydrophobic basic drugs in pharmaceutical preparations. Biomedical Chromatography. 21(1):21-28. https://doi.org/10.1002/bmc.710 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1002/bmc.710 | es_ES |
dc.description.upvformatpinicio | 21 | es_ES |
dc.description.upvformatpfin | 28 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 21 | es_ES |
dc.description.issue | 1 | es_ES |
dc.relation.senia | 30560 | |
dc.identifier.pmid | 17080499 | |
dc.contributor.funder | Ministerio de Educación y Ciencia | |
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