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Automated simultaneous triple dissolution profiles of two drugs, sulphametoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosage forms by a multicommutation flow-assembly and derivative spectrophotometry

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Automated simultaneous triple dissolution profiles of two drugs, sulphametoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosage forms by a multicommutation flow-assembly and derivative spectrophotometry

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dc.contributor.author Tomsu, D. es_ES
dc.contributor.author Catalá Icardo, Mónica es_ES
dc.contributor.author Martínez Calatayud, J. es_ES
dc.date.accessioned 2015-10-01T16:20:21Z
dc.date.available 2015-10-01T16:20:21Z
dc.date.issued 2004-11-15
dc.identifier.issn 0731-7085
dc.identifier.uri http://hdl.handle.net/10251/55457
dc.description.abstract This article deals with the simultaneous determination of three dissolution profiles with the aid of the new and emerging continuous-flow methodology known as multicommutation. This methodology is based on a flow network of a set of solenoid valves controlled by the computer and acting as independent multicommutators to allow the easy and automated control of flowing solutions. The obtained three dissolution profiles from one dosage form are the whole formulation profile or "global profile" recommended by pharmacopoeias, and, at same time, are recorded two "individual" profiles from two drugs present in the formulation. This is the second attempt to obtain simultaneously three dissolution profiles with a single spectrophotometric detector and the first with the multicommutation methodology. The selected pharmaceutical formulations contained a couple of active principles with overlapped spectra, namely sulphamethoxazole and trimethoprim or hydrochlorothiazide and captopril. The obtained empirical plots profiles fitted with the Higuchi equation also known as the three-parameter equation. (C) 2004 Elsevier B.V. All rights reserved. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Journal of Pharmaceutical and Biomedical Analysis es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Pharmaceuticals es_ES
dc.subject Dissolution profiles es_ES
dc.subject In vitro availability es_ES
dc.subject Solenoid valves multicommutation es_ES
dc.subject Sulphamethoxazole es_ES
dc.subject Trimethoprim es_ES
dc.subject Hydrochlorothiazide es_ES
dc.subject Captopril es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Automated simultaneous triple dissolution profiles of two drugs, sulphametoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosage forms by a multicommutation flow-assembly and derivative spectrophotometry es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jpba.2004.07.009
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres es_ES
dc.description.bibliographicCitation Tomsu, D.; Catalá Icardo, M.; Martínez Calatayud, J. (2004). Automated simultaneous triple dissolution profiles of two drugs, sulphametoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosage forms by a multicommutation flow-assembly and derivative spectrophotometry. Journal of Pharmaceutical and Biomedical Analysis. 36(3):549-557. doi:10.1016/j.jpba.2004.07.009 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jpba.2004.07.009 es_ES
dc.description.upvformatpinicio 549 es_ES
dc.description.upvformatpfin 557 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 36 es_ES
dc.description.issue 3 es_ES
dc.relation.senia 25857
dc.identifier.eissn 1873-264X


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