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A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability

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A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability

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Rodríguez Berna, G.; Mangas Sanjuan, V.; Gonzalez Alvarez, M.; Gonzalez Álvarez, I.; Garcia Gimenez, JL.; Díaz Cabañas, MJ.; Bermejo, M.... (2014). A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. European Journal of Medicinal Chemistry. 83:366-373. doi:10.1016/j.ejmech.2014.06.050

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/56302

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Title: A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability
Author: Rodríguez Berna, Guillermo Mangas Sanjuan, Victor Gonzalez Alvarez, Marta Gonzalez Álvarez, Isabel Garcia Gimenez, Jose Luis Díaz Cabañas, Mª José Bermejo, Marival Corma Canós, Avelino
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
Oral administration of camptothecin (Cm) derivatives and other antitumoral agents is being actively developed in order to improve the quality of life of patients with cancer. Though several lipophilic derivatives of CPT ...[+]
Subjects: Dioxinocamptothecin , Antitumor , Camptothecin , Oral , Permeability , Transport
Copyrigths: Reserva de todos los derechos
Source:
European Journal of Medicinal Chemistry. (issn: 0223-5234 ) (eissn: 1768-3254 )
DOI: 10.1016/j.ejmech.2014.06.050
Publisher:
Elsevier
Publisher version: http://dx.doi.org/10.1016/j.ejmech.2014.06.050
Project ID:
info:eu-repo/grantAgreement/EC//DCI-ALA%2F19.09.01%2F10%2F21526%2F245-297%2FALFA III(2010)29/
Thanks:
G.R.-B. acknowledges Instituto de Tecnologia Quimica for a scholarship; Consolider-Ingenio 2010 (proyecto MULTICAT), Sub-programa de Apoyo a Centros de Excelencia Severo Ochoa, and Agencia de Gestico, d'Ajuts Universiteris ...[+]
Type: Artículo

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