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Primary ciliary dyskinesia assessment by means of optical flow analysis of phase-contrast microscopy images

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Primary ciliary dyskinesia assessment by means of optical flow analysis of phase-contrast microscopy images

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dc.contributor.author Parrilla Bernabé, Eduardo es_ES
dc.contributor.author Armengot, Miguel es_ES
dc.contributor.author Mata, Manuel es_ES
dc.contributor.author Sánchez Vílchez, José Manuel es_ES
dc.contributor.author Cortijo, Julio es_ES
dc.contributor.author Hueso Pagoaga, José Luís es_ES
dc.contributor.author Riera Guasp, Jaime es_ES
dc.contributor.author Moratal Pérez, David es_ES
dc.date.accessioned 2015-11-24T09:23:01Z
dc.date.available 2015-11-24T09:23:01Z
dc.date.issued 2014-04
dc.identifier.issn 0895-6111
dc.identifier.uri http://hdl.handle.net/10251/57980
dc.description.abstract Primary ciliary dyskinesia implies cilia with defective or total absence of motility, which may result in sinusitis, chronic bronchitis, bronchiectasis and male infertility. Diagnosis can be difficult and is based on an abnormal ciliary beat frequency (CBF) and beat pattern. In this paper, we present a method to determine CBF of isolated cells through the analysis of phase-contrast microscopy images, estimating cilia motion by means of an optical flow algorithm. After having analyzed 28 image sequences (14 with a normal beat pattern and 14 with a dyskinetic pattern), the normal group presented a CBF of 5.2 +/- 1.6 Hz, while the dyskinetic patients presented a 1.9 +/- 0.9 Hz CBF. The cutoff value to classify a dyskinetic specimen was set to 3.45 Hz (sensitivity 0.86, specificity 0.93). The presented methodology has provided excellent results to objectively diagnose PCD. es_ES
dc.description.sponsorship The support of the Vicerectorado de Investigacion of the Universitat Politecnica de Valencia through project "Proyectos de Nuevas Libeas de Investigacion Multidisciplinares" PAID-05-10/2697 is greatly acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Vicerectorado de Investigacion of the Universitat Politecnica de Valencia through project "Proyectos de Nuevas Libeas de Investigacion Multidisciplinares" PAID-05-10/2697 es_ES
dc.relation.ispartof Computerized Medical Imaging and Graphics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Active contours es_ES
dc.subject Beat frequency es_ES
dc.subject Fourier-Mellin transform es_ES
dc.subject Optical flow es_ES
dc.subject Primary ciliary dyskinesia es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Primary ciliary dyskinesia assessment by means of optical flow analysis of phase-contrast microscopy images es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.compmedimag.2013.12.010
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Tecnología Nanofotónica - Institut Universitari de Tecnologia Nanofotònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biomecánica de Valencia - Institut Universitari Mixt de Biomecànica de València es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Matemática Multidisciplinar - Institut Universitari de Matemàtica Multidisciplinària es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Parrilla Bernabé, E.; Armengot, M.; Mata, M.; Sánchez Vílchez, JM.; Cortijo, J.; Hueso Pagoaga, JL.; Riera Guasp, J.... (2014). Primary ciliary dyskinesia assessment by means of optical flow analysis of phase-contrast microscopy images. Computerized Medical Imaging and Graphics. 38(3):163-170. doi:10.1016/j.compmedimag.2013.12.010 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.compmedimag.2013.12.010 es_ES
dc.description.upvformatpinicio 163 es_ES
dc.description.upvformatpfin 170 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 38 es_ES
dc.description.issue 3 es_ES
dc.relation.senia 279482 es_ES


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