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dc.contributor.author | Compañ Moreno, Vicente | es_ES |
dc.contributor.author | Oliveira, Cristina | es_ES |
dc.contributor.author | Aguilella-Arzo, Marcel | es_ES |
dc.contributor.author | Mollá Romano, Sergio | es_ES |
dc.contributor.author | Peixoto-de-Matos, Sofia C. | es_ES |
dc.contributor.author | Gonzalez-Meijome, Jose M. | es_ES |
dc.date.accessioned | 2016-01-08T09:13:16Z | |
dc.date.issued | 2014-10 | |
dc.identifier.issn | 0146-0404 | |
dc.identifier.uri | http://hdl.handle.net/10251/59539 | |
dc.description.abstract | PURPOSE. We defined the theoretical oxygen tension behind modern scleral contact lenses (CLs) made of different rigid gas permeable (RGP) materials, assuming different thickness of the tear layer behind the lens. A second goal was to show clinically the effect of the postlens tear film on corneal swelling. METHODS. We simulated the partial pressure of oxygen across the cornea behind scleral CLs made of different lens materials (oxygen permeability Dk, 75-200 barrer) and different thickness (T-av, 100-300 mu m). Postlens tear film thicknesses (Tpost-tear) ranging from 150 to 350 mu m were considered. Eight healthy subjects were fitted randomly with a scleral lens with a thin and a thick postlens tear layer in two different sessions for a period of 3 hours under open-eye conditions. RESULTS. The CLs with less than 125 barrer of Dk and a thickness over 200 mu m depleted the oxygen availability at the lens-cornea interface below 55 mm Hg for a postlens tear film of 150 mu m. For a postlens tear film thickness of 350 mu m, no combination of material or lens thickness will meet the criteria of 55 mm Hg. Our clinical measures of corneal edema showed that this was significantly higher (P < 0.001, Wilcoxon signed ranks test) with the thicker compared to the thinner Tpost-tear (mean +/- SD, 1.66 +/- 1.12 vs. 4.27 +/- 1.19%). CONCLUSIONS. Scleral RGP CLs must be comprised of at least 125 barrer of oxygen permeability and up to 200 mu m thick to avoid hypoxic effects even under open eye conditions. Postlens tear film layer should be below 150 mu m to avoid clinically significant edema. | es_ES |
dc.description.sponsorship | Supported by the Ministerio de Educacion y Ciencia (MEC) through Project ENE2011-24761, and by FEDER through the COMPETE Program and by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Project PEST-C/FIS/UI607/2011. The authors alone are responsible for the content and writing of the paper. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Association for Research in Vision and Ophthalmology (ARVO) | es_ES |
dc.relation.ispartof | Investigative Ophthalmology & Visual Science | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | scleral lenses | es_ES |
dc.subject | oxygen transmissibility | es_ES |
dc.subject | corneal edema | es_ES |
dc.subject | tear film | es_ES |
dc.subject | boundary layers | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Oxygen diffusion and Edema with Modern Scleral Rigid Gas Permeable Contact Lenses | es_ES |
dc.type | Artículo | es_ES |
dc.embargo.lift | 10000-01-01 | |
dc.embargo.terms | forever | es_ES |
dc.identifier.doi | 10.1167/iovs.14-14038 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//ENE2011-24761/ES/DESARROLLO DE NUEVOS DISPOSITIVOS IONICOS PARA LA PRODUCCION EFICIENTE Y SOSTENIBLE DE ENERGIA Y PRODUCTOS QUIMICOS%2FCOMBUSTIBLES/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/FCT//PEST-C%2FFIS%2FUI607%2F2011/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Compañ Moreno, V.; Oliveira, C.; Aguilella-Arzo, M.; Mollá Romano, S.; Peixoto-De-Matos, SC.; Gonzalez-Meijome, JM. (2014). Oxygen diffusion and Edema with Modern Scleral Rigid Gas Permeable Contact Lenses. Investigative Ophthalmology & Visual Science. 55(10):6421-6429. https://doi.org/10.1167/iovs.14-14038 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1167/iovs.14-14038 | es_ES |
dc.description.upvformatpinicio | 6421 | es_ES |
dc.description.upvformatpfin | 6429 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 55 | es_ES |
dc.description.issue | 10 | es_ES |
dc.relation.senia | 282238 | es_ES |
dc.contributor.funder | Fundação para a Ciência e a Tecnologia, Portugal | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |