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Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants

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Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants

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dc.contributor.author Mulet Salort, José Miguel es_ES
dc.contributor.author Llopis Torregrosa, Vicent es_ES
dc.contributor.author Primo Planta, Cecilia es_ES
dc.contributor.author Marques Romero, Mª Carmen es_ES
dc.contributor.author Yenush, Lynne es_ES
dc.date.accessioned 2016-01-27T11:06:03Z
dc.date.available 2016-01-27T11:06:03Z
dc.date.issued 2013-11
dc.identifier.issn 0172-8083
dc.identifier.uri http://hdl.handle.net/10251/60256
dc.description.abstract The relative concentrations of ions and solutes inside cells are actively maintained by several classes of transport proteins, in many cases against their concentration gradient. These transport processes, which consume a large portion of cellular energy, must be constantly regulated. Many structurally distinct families of channels, carriers, and pumps have been characterized in considerable detail during the past decades and defects in the function of some of these proteins have been linked to a growing list of human diseases. The dynamic regulation of the transport proteins present at the cell surface is vital for both normal cellular function and for the successful adaptation to changing environments. The composition of proteins present at the cell surface is controlled on both the transcriptional and post-translational level. Post-translational regulation involves highly conserved mechanisms of phosphorylation- and ubiquitylation-dependent signal transduction routes used to modify the cohort of receptors and transport proteins present under any given circumstances. In this review, we will summarize what is currently known about one facet of this regulatory process: the endocytic regulation of alkali metal transport proteins. The physiological relevance, major contributors, parallels and missing pieces of the puzzle in mammals, yeast and plants will be discussed. es_ES
dc.description.sponsorship This work was supported by grant BFU2011-30197-C03-03 from the Ministerio de Ciencia e Innovacion (Spain). V.L.-T. is supported by a fellowship from the Universidad Politecnica de Valencia. C. P. is supported by a fellowship from the Consejo Superior de Investigaciones Cientificas (Spain). en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof Current Genetics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Ion homeostasis es_ES
dc.subject Endocytic regulation es_ES
dc.subject Ubiquitylation es_ES
dc.subject ESCRT es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00294-013-0401-2
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BFU2011-30197-C03-03/ES/PAPEL DEL TRAFICO DE PROTEINAS EN LA HOMEOSTASIS DE IONES Y NUTRIENTES EN LEVADURA Y PLANTAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Mulet Salort, JM.; Llopis Torregrosa, V.; Primo Planta, C.; Marques Romero, MC.; Yenush, L. (2013). Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants. Current Genetics. 59(4):207-230. https://doi.org/10.1007/s00294-013-0401-2 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s00294-013-0401-2 es_ES
dc.description.upvformatpinicio 207 es_ES
dc.description.upvformatpfin 230 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 59 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 251058 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Consejo Superior de Investigaciones Científicas es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
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