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dc.contributor.author | Bonancía Roca, Paula![]() |
es_ES |
dc.contributor.author | Vayá Pérez, Ignacio![]() |
es_ES |
dc.contributor.author | Climent Olmedo, María José![]() |
es_ES |
dc.contributor.author | Gustavsson, Thomas![]() |
es_ES |
dc.contributor.author | Markovitsi, Dimitra![]() |
es_ES |
dc.contributor.author | Jiménez Molero, María Consuelo![]() |
es_ES |
dc.contributor.author | Miranda Alonso, Miguel Ángel![]() |
es_ES |
dc.date.accessioned | 2016-02-16T12:55:17Z | |
dc.date.issued | 2012-09-06 | |
dc.identifier.issn | 1089-5639 | |
dc.identifier.uri | http://hdl.handle.net/10251/60930 | |
dc.description.abstract | Excited-state interactions between (S)- or (R) fluorescence (S)- or (R)-FBP) and thymidine (dThd) covalently linked in dyads 1 or 2 have been investigated. In both dyads, the only emitting species is (FBP)-F-1*, but with a lower fluorescence quantum yield (phi(F)) and a shorter fluorescene lifetime (tau(F)) than when free in solution. These an results indicate that dynamic quenching occurs either by electron transfer or via exciplex formation, with FBP as the charge-donating species. In acetonitrile, both mechanisms are favored, while in dioxane exciplex formation is predominating. Isomer 1 displays lower values of OF and rF than its analogue 2, indicating that the relative spatial arrangement of the chromophores plays a significant role. The triplet quantum yields (0-F) of 1 and 2 are significantly higher than the expectations based solely on 'FBP* dThd intersystem crossing quantum yields (Oisc), with OT (1) > OT (2). This can be explained in terms of intramolecular charge recombination at the radical ion pairs and/or the exciplexes, which would be again dependent on geometrical factors. The triplet lifetimes (IT) of 3FBP* dThd and free 3FBP* are similar, indicating the lack of excited-state interactions at this stage. The FBP dThd dyads could, in principle, constitute appropriate model systems for the elucidation of the excited-state interactions in noncovalent DNA ligand complexes. | es_ES |
dc.description.sponsorship | Financial support from the Spanish Government (Grants CTQ2010-14882 and CTQ2009-13699), Salvador Madariaga Program (Grant to M.C.J.), Juan de la Cierva Program (contract to I.V.), Generalitat Valenciana (Prometeo 2008/090), and the Universitat Politecnica de Valencia (PAID 05-11, ref 2766) is gratefully acknowledged. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | Journal of Physical Chemistry A | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | TRANSIENT ABSORPTION-SPECTROSCOPY | es_ES |
dc.subject | BOVINE SERUM ALBUMINS | es_ES |
dc.subject | ELECTRON-TRANSFER | es_ES |
dc.subject | DNA | es_ES |
dc.subject | FLUORESCENCE | es_ES |
dc.subject | DIMER | es_ES |
dc.subject | TRANSPORT | es_ES |
dc.subject | DRUGS | es_ES |
dc.subject | DERIVATIVES | es_ES |
dc.subject | PROTEINS | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.title | Excited-state interactions in diastereomeric flurbiprofen-thymine dyads | es_ES |
dc.type | Artículo | es_ES |
dc.embargo.lift | 10000-01-01 | |
dc.embargo.terms | forever | es_ES |
dc.identifier.doi | 10.1021/jp3063838 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//CTQ2010-14882/ES/DIADAS FOTOACTIVAS COMO SONDAS PARA LA GENERACION DE ESPECIES TRANSITORIAS EN SISTEMAS MICROHETEROGENEOS DE TIPO BIOMIMETICO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UPV//PAID-05-11-2766/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/CTQ2009-13699/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Bonancía Roca, P.; Vayá Pérez, I.; Climent Olmedo, MJ.; Gustavsson, T.; Markovitsi, D.; Jiménez Molero, MC.; Miranda Alonso, MÁ. (2012). Excited-state interactions in diastereomeric flurbiprofen-thymine dyads. Journal of Physical Chemistry A. 116(35):8807-8814. https://doi.org/10.1021/jp3063838 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jp3063838 | es_ES |
dc.description.upvformatpinicio | 8807 | es_ES |
dc.description.upvformatpfin | 8814 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 116 | es_ES |
dc.description.issue | 35 | es_ES |
dc.relation.senia | 233789 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |