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Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer

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Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer

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Nuin Plá, NE.; Jiménez Molero, MC.; Sastre Navarro, GI.; Andreu Ros, MI.; Miranda Alonso, MÁ. (2013). Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer. Journal of Physical Chemistry Letters. 4(10):1603-1607. https://doi.org/10.1021/jz400640s

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Title: Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer
Author: Nuin Plá, Neus Edurne Jiménez Molero, María Consuelo Sastre Navarro, German Ignacio Andreu Ros, María Inmaculada Miranda Alonso, Miguel Ángel
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...[+]
Subjects: TRANSIENT ABSORPTION-SPECTROSCOPY , HUMAN ALPHA(1)-ACID GLYCOPROTEIN , BOVINE SERUM ALBUMINS , EXCITED-STATES , ALPHA1-ACID GLYCOPROTEIN , TRANSPORTER PROTEIN , BINDING , FLURBIPROFEN , METABOLISM , PREDICTION
Copyrigths: Cerrado
Source:
Journal of Physical Chemistry Letters. (issn: 1948-7185 )
DOI: 10.1021/jz400640s
Publisher:
American Chemical Society
Publisher version: http://dx.doi.org/10.1021/jz400640s
Project ID:
info:eu-repo/grantAgreement/MICINN//CTQ2010-14882/ES/DIADAS FOTOACTIVAS COMO SONDAS PARA LA GENERACION DE ESPECIES TRANSITORIAS EN SISTEMAS MICROHETEROGENEOS DE TIPO BIOMIMETICO/
info:eu-repo/grantAgreement/MICINN//CP11%2F00154/ES/CP11%2F00154/
info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/CTQ2009-13699/
Thanks:
Financial support from the Spanish Government (CTQ2009-13699, CTQ2010-14882) and from the Carlos III Institute of Health (Grant RIRAAF, RETICS program, and Miguel Servet Contract CP11/00154 for I.A.) is gratefully acknowledged.[+]
Type: Artículo

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