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Fluoroquinolone photodegradation influences specific basophil activation

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Fluoroquinolone photodegradation influences specific basophil activation

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dc.contributor.author Mayorga, Cristobalina es_ES
dc.contributor.author Andreu Ros, María Inmaculada es_ES
dc.contributor.author Aranda, Ana es_ES
dc.contributor.author Doña, Inmaculada es_ES
dc.contributor.author Montañez, M. Isabel es_ES
dc.contributor.author Blanca-López, Natalia es_ES
dc.contributor.author Ariza, Adriana es_ES
dc.contributor.author Nuin Plá, Neus Edurne es_ES
dc.contributor.author Blanca, Miguel es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Torres, Mª José es_ES
dc.date.accessioned 2016-02-17T15:39:55Z
dc.date.available 2016-02-17T15:39:55Z
dc.date.issued 2013
dc.identifier.issn 1018-2438
dc.identifier.uri http://hdl.handle.net/10251/60966
dc.description.abstract Fluoroquinolones (FQs) are photoreactive drugs, but it is not known whether laboratory light exposure can influence the induction of photoproducts and modify in vitro test results. The basophil activation test (BAT) has proven to be useful for evaluating immunoglobulin E (IgE)-mediated hypersensitivity to FQs, with a higher percentage of positive responders with ciprofloxacin (CIP) than with moxifloxacin (MOX). We studied the effect of laboratory light on CIP and MOX degradation, and drug-protein conjugate formation, and its influence on the BAT for evaluating IgE-mediated hypersensitivity to FQs. The results showed an important decrease in fluorescence emission intensity under light compared to dark conditions for MOX, and that BAT positivity was lower in light (17.9%) than in dark (35.7%) conditions. No changes were found for CIP in either fluorescence emission intensity or BAT results (46.4% in both conditions). We can conclude that light exposure is a critical factor in BAT results when photolabile drugs like MOX are used. Therefore, light is important when interpreting in vitro results. Copyright (C) 2012 S. Karger AG, Basel es_ES
dc.description.sponsorship We thank Ian Johnstone for his help with the English language version of the manuscript, and Jose Luis Rodriguez-Bada and Lidia Melendez for their technical support. This study was funded by the FIS-Thematic Networks and Co-operative Research Centres: RIRAAF (RD07/0064) and the Spanish Health Ministry (FIS PS09/01768, PI11/01416 and M Servet contract CP11/00154 for I.A.), the Andalusia Health Ministry (PI-0545-2010), and the Andalusia Economic Innovation and Science Ministry (CTS 06603). en_EN
dc.language Inglés es_ES
dc.publisher Karger es_ES
dc.relation.ispartof International Archives of Allergy and Immunology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Allergy es_ES
dc.subject Basophil activation es_ES
dc.subject Immunoglobulin E es_ES
dc.subject Quinolones es_ES
dc.subject Photodegradation es_ES
dc.subject Hapten-protein conjugates es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Fluoroquinolone photodegradation influences specific basophil activation es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1159/000343023
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//RD07%2F0064/ES/RED DE INVESTIGACION DE REACCIONES ADVERSAS A ALERGENOS Y FARMACOS (RIRAAF)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PS09%2F01768/ES/RESPUESTA IGE A ANTIBIOTICOS BETALACTAMICOS: ANALISIS DE LA CONTRIBUCION DE DIFERENTES ESTRUCTURAS QUIMICAS AL RECONOCIMIENTO POR LOS ANTICUERPOS E IDENTIFICACION DE PROTEINAS CANDIDATAS./ / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Junta de Andalucía//PI-0545-2010/ES/Diseño de nanoestructuras sintéticas hapteno-portador para la detección de anticuerpos IgE en reacciones de hipersensibilidad a betalactámicos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Junta de Andalucía//CTS 06603/ES/Desarrollo de prototipos experimentales de conjugados hapteno-carrier para aplicación diagnóstica en las reacciones de hipersensibilidad a fármacos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PI11%2F01416/ES/Desarrollo de prototipos experimentales de haptenos y conjugados hapteno-carrier para aplicación diagnóstica en las reacciones de hipersensibilidad a fármacos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CP11%2F00154/ES/CP11%2F00154/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Mayorga, C.; Andreu Ros, MI.; Aranda, A.; Doña, I.; Montañez, MI.; Blanca-López, N.; Ariza, A.... (2013). Fluoroquinolone photodegradation influences specific basophil activation. International Archives of Allergy and Immunology. 160(4):377-382. https://doi.org/10.1159/000343023 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1159/000343023 es_ES
dc.description.upvformatpinicio 377 es_ES
dc.description.upvformatpfin 382 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 160 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 237726 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Junta de Andalucía es_ES
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