Multivariate image analysis and near infrared chemical imaging for characterisation of micro-mixing in polymeric thin films

Abstract

This article introduces a methodology for efficiently analysing hyperspectral images from pharmaceutical formulations. It provides information on the relative concentration and spatial distribution of active pharmamceutical ingredient and excipient in the formulation as well as on the internal correlation structure of the mixture by the use of multivariate image analysis, which provides insight information about the different underlying phenomena in the images (hence about the process).