- -

Characterization of complex fractionated atrial electrograms by Sample Entropy: An international multi-center study

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Characterization of complex fractionated atrial electrograms by Sample Entropy: An international multi-center study

Show simple item record

Files in this item

dc.contributor.author Cirugeda Roldán, Eva María es_ES
dc.contributor.author Novak, Daniel es_ES
dc.contributor.author Kremen, Vaclav es_ES
dc.contributor.author Cuesta Frau, David es_ES
dc.contributor.author Keller, Matthias es_ES
dc.contributor.author Luik, Armin es_ES
dc.contributor.author Srutova, Martina es_ES
dc.date.accessioned 2016-03-15T08:54:56Z
dc.date.available 2016-03-15T08:54:56Z
dc.date.issued 2015-11
dc.identifier.issn 1099-4300
dc.identifier.uri http://hdl.handle.net/10251/61865
dc.description.abstract Atrial fibrillation (AF) is the most commonly clinically-encountered arrhythmia. Catheter ablation of AF is mainly based on trigger elimination and modification of the AF substrate. Substrate mapping ablation of complex fractionated atrial electrograms (CFAEs) has emerged to be a promising technique. To improve substrate mapping based on CFAE analysis, automatic detection algorithms need to be developed in order to simplify and accelerate the ablation procedures. According to the latest studies, the level of fractionation has been shown to be promisingly well estimated from CFAE measured during radio frequency (RF) ablation of AF. The nature of CFAE is generally nonlinear and nonstationary, so the use of complexity measures is considered to be the appropriate technique for the analysis of AF records. This work proposes the use of sample entropy (SampEn), not only as a way to discern between non-fractionated and fractionated atrial electrograms (A-EGM), but also as a tool for characterizing the degree of A-EGM regularity, which is linked to changes in the AF substrate and to heart tissue damage. The use of SampEn combined with a blind parameter estimation optimization process enables the classification between CFAE and non-CFAE with statistical significance (p < 0:001), 0.89 area under the ROC, 86% specificity and 77% sensitivity over a mixed database of A-EGM combined from two independent CFAE signal databases, recorded during RF ablation of AF in two EU countries (542 signals in total). On the basis of the results obtained in this study, it can be suggested that the use of SampEn is suitable for real-time support during navigation of RF ablation of AF, as only 1.5 seconds of signal segments need to be analyzed. es_ES
dc.description.sponsorship This work has been supported by the Spanish Ministry of Science and Innovation, Research Project TEC 2009-14222, by the Ministry of Education Youth and Sports of the Czech Republic, the Grant Agency of the Czech Technical University in Prague No. SGS13/203/OHK3/3T/13 and by the Czech Science 300 Foundation post-doctoral GACR research project GACR #P103/11/P106. en_EN
dc.language Inglés es_ES
dc.publisher MDPI es_ES
dc.relation Spanish Ministry of Science and Innovation TEC 2009-14222 es_ES
dc.relation Ministry of Education Youth and Sports of the Czech Republic es_ES
dc.relation Grant Agency of the Czech Technical University in Prague SGS13/203/OHK3/3T/13 es_ES
dc.relation Czech Science 300 Foundation post-doctoral GACR research project P103/11/P106 es_ES
dc.relation.ispartof Entropy es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Atrial fibrillation es_ES
dc.subject Catheter ablation es_ES
dc.subject Complex fractionated atrial electrograms es_ES
dc.subject Sample entropy es_ES
dc.subject Signal classification es_ES
dc.subject.classification ARQUITECTURA Y TECNOLOGIA DE COMPUTADORES es_ES
dc.title Characterization of complex fractionated atrial electrograms by Sample Entropy: An international multi-center study es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/e17117493
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto Tecnológico de Informática - Institut Universitari Mixt Tecnològic d'Informàtica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Informática de Sistemas y Computadores - Departament d'Informàtica de Sistemes i Computadors es_ES
dc.description.bibliographicCitation Cirugeda Roldán, EM.; Novak, D.; Kremen, V.; Cuesta Frau, D.; Keller, M.; Luik, A.; Srutova, M. (2015). Characterization of complex fractionated atrial electrograms by Sample Entropy: An international multi-center study. Entropy. 17(11):7493-7509. doi:10.3390/e17117493 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.3390/e17117493 es_ES
dc.description.upvformatpinicio 7493 es_ES
dc.description.upvformatpfin 7509 es_ES
dc.type.version info:eu repo/semantics/publishedVersion es_ES
dc.description.volume 17 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 299164 es_ES
dc.identifier.eissn 1099-4300


This item appears in the following Collection(s)

Show simple item record