Ultimo, A.; Giménez Morales, C.; Bartovsky, P.; Aznar, E.; Sancenón Galarza, F.; Marcos Martínez, MD.; Amoros Del Toro, PJ.... (2016). Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells. Chemistry - A European Journal. 22(5):1582-1586. doi:10.1002/chem.201504629
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/62279
Title:
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Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells
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Author:
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Ultimo, Amelia
Giménez Morales, Cristina
BARTOVSKY, PAVEL
Aznar, Elena
Sancenón Galarza, Félix
Marcos Martínez, María Dolores
Amoros del Toro, Pedro Jose
Bernardo, Ana R.
Martínez-Máñez, Ramón
Jiménez Lara, Ana M.
Murguía, Jose R.
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UPV Unit:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
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Issued date:
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Abstract:
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The authors describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for ...[+]
The authors describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK-BR-3 breast carcinoma cells. The authors' results show that poly(I:C)-conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA-TLR3 interaction. Such interaction also triggered apoptotic pathways in SK-BR-3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles' mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
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Subjects:
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Antitumor agents
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Breast carcinoma
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Drug delivery
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Mesoporous gated materials
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Polyinosinic polycytidylic acid
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Chemistry - A European Journal. (issn:
0947-6539
) (eissn:
1521-3765
)
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DOI:
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10.1002/chem.201504629
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Publisher:
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Wiley
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Publisher version:
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http://dx.doi.org/10.1002/chem.201504629
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Project ID:
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Spanish Government SAF2010-21195 MAT2012-38429-C04-01
Generalitat Valenciana PROMETEOII/2014/047
Ministry of Education, Culture and Sport
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Thanks:
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We thank the Spanish Government (projects SAF2010-21195 and MAT2012-38429-C04-01) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. A.U. and C.G. are grateful to the Ministry of Education, Culture ...[+]
We thank the Spanish Government (projects SAF2010-21195 and MAT2012-38429-C04-01) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. A.U. and C.G. are grateful to the Ministry of Education, Culture and Sport for their doctoral fellowships. We thank J. M. Cosgaya and M. J. Latasa for helpful discussions.
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Type:
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Artículo
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