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Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy; a randomised, double-blind, placebo-controlled trial

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Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy; a randomised, double-blind, placebo-controlled trial

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dc.contributor.author Garcia-Peris, P. es_ES
dc.contributor.author Velasco, C. es_ES
dc.contributor.author Lozano, M. A. es_ES
dc.contributor.author Moreno Trigos, Mª Yolanda es_ES
dc.contributor.author Paron, L. es_ES
dc.contributor.author de la Cuerda, C. es_ES
dc.contributor.author Breton, I. es_ES
dc.contributor.author Camblor, M. es_ES
dc.contributor.author García Hernández, Jorge es_ES
dc.contributor.author Guarner, F. es_ES
dc.contributor.author Hernández Pérez, Manuel es_ES
dc.date.accessioned 2016-04-28T12:05:02Z
dc.date.available 2016-04-28T12:05:02Z
dc.date.issued 2012
dc.identifier.issn 0212-1611
dc.identifier.uri http://hdl.handle.net/10251/63110
dc.description.abstract Background & aims: The pathogenesis of enteritis after abdominal radiotherapy is unknown, although changes in faecal microbiota may be involved. In several studies, Lactobacillus and Bifidobacterium have proven beneficial for the host. Prebiotics stimulate the proliferation of Lactobacillus and Bifidobacterium, and this may have positive effects on the intestinal mucosa during abdominal radiotherapy. Methods: We performed a randomised double-blind, placebo-controlled trial including 31 patients with gynaecological cancer who received radiotherapy (29 sessions, 52.2 Gy) after surgery. Patients were randomised to two groups: prebiotic and placebo. The first group received a mixture of fibre (50% inulin and 50% fructo-oligosaccharide) and the second received 6 g of maltodextrin twice daily from one week before to three weeks after radiotherapy. Lactobacillus and Bifidobacterium counts were determined in faeces samples (day 7 before radiotherapy, day 15 of radiotherapy, at the end of treatment, and three weeks after radiotherapy) by culture in selective media and fluorescent in situ hybridization (FISH) using genus-specific probes. Bacterial counts by FISH were significantly higher than by culture method. Results: There were no differences in baseline microbiota between groups. At the end of radiotherapy, we observed a statistically significant decrease in Lactobacillus and Bifidobacterium counts in both groups. By cultural analysis, we observed higher numbers of Lactobacillus and Bifidobacterium three weeks after radiotherapy in the prebiotic group (5.6 vs. 6.3, p = 0.04 and 5.5 vs. 6 log cfu/g, p = 0.03). Conclusions: Abdominal radiotherapy negatively affects Lactobacillus and Bifidobacterium counts. The prebiotic mixture of inulin and fructoligosaccharide can improve the recovery of both genera after radiotherapy. es_ES
dc.description.sponsorship This work was supported in part by grants from Vegenat (Spain). en_EN
dc.language Inglés es_ES
dc.publisher AULA MEDICA EDICIONES es_ES
dc.relation.ispartof Nutricion Hospitalaria es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Inuline es_ES
dc.subject Lactobacillus es_ES
dc.subject Bifidobacterium es_ES
dc.subject Radiotherapy es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.title Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy; a randomised, double-blind, placebo-controlled trial es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3305/nh.2012.27.6.5992
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro Avanzado de Microbiología de Alimentos - Centre Avançat de Microbiologia d'Aliments es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Ingeniería del Agua y del Medio Ambiente - Institut Universitari d'Enginyeria de l'Aigua i Medi Ambient es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Garcia-Peris, P.; Velasco, C.; Lozano, MA.; Moreno Trigos, MY.; Paron, L.; De La Cuerda, C.; Breton, I.... (2012). Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy; a randomised, double-blind, placebo-controlled trial. Nutricion Hospitalaria. 27(6):1908-1915. doi:10.3305/nh.2012.27.6.5992 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.3305/nh.2012.27.6.5992 es_ES
dc.description.upvformatpinicio 1908 es_ES
dc.description.upvformatpfin 1915 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 27 es_ES
dc.description.issue 6 es_ES
dc.relation.senia 232824 es_ES
dc.contributor.funder Vegenat, S.A.


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