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Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering

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Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering

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dc.contributor.author Vikingsson, Line Karina Alva es_ES
dc.contributor.author Claessens, B. es_ES
dc.contributor.author Gómez Tejedor, José Antonio es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2016-05-04T14:32:42Z
dc.date.available 2016-05-04T14:32:42Z
dc.date.issued 2015-08
dc.identifier.issn 1751-6161
dc.identifier.uri http://hdl.handle.net/10251/63634
dc.description.abstract In tissue engineering the design and optimization of biodegradable polymeric scaffolds with a 3D-structure is an important field. The porous scaffold provide the cells with an adequate biomechanical environment that allows mechanotransduction signals for cell differentiation and the scaffolds also protect the cells from initial compressive loading. The scaffold have interconnected macro-pores that host the cells and newly formed tissue, while the pore walls should be micro-porous to transport nutrients and waste products. Polycaprolactone (PCL) scaffolds with a double micro- and macro-pore architecture have been proposed for cartilage regeneration. This work explores the influence of the micro-porosity of the pore walls on water permeability and scaffold compliance. A Poly(Vinyl Alcohol) with tailored mechanical properties has been used to simulate the growing cartilage tissue inside the scaffold pores. Unconfined and confined compression tests were performed to characterize both the water permeability and the mechanical response of scaffolds with varying size of micro-porosity while volume fraction of the macro-pores remains constant. The stress relaxation tests show that the stress response of the scaffold/ hydrogel construct is a synergic effect determined by the performance of the both components. This is interesting since it suggests that the in vivo outcome of the scaffold is not only dependent upon the material architecture but also the growing tissue inside the scaffold's pores. On the other hand, confined compression results show that compliance of the scaffold is mainly controlled by the micro-porosity of the scaffold and less by hydrogel density in the scaffold pores. These conclusions bring together valuable information for customizing the optimal scaffold and to predict the in vivo mechanical behavior. es_ES
dc.description.sponsorship The authors gratefully acknowledge the financial support from the Spanish Ministry of Economy and Competitiveness through the MAT2013-46467-C4-1-R project, including FEDER funds. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with the assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Journal of the Mechanical Behavior of Biomedical Materials es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Porous scaffolds es_ES
dc.subject Permeability es_ES
dc.subject Polycaprolactone es_ES
dc.subject Poly (vinyl alcohol) es_ES
dc.subject Freezing and thawing es_ES
dc.subject Mechanical properties es_ES
dc.title Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jmbbm.2015.03.021
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Vikingsson, LKA.; Claessens, B.; Gómez Tejedor, JA.; Gallego-Ferrer, G.; Gómez Ribelles, JL. (2015). Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering. Journal of the Mechanical Behavior of Biomedical Materials. 48:60-69. https://doi.org/10.1016/j.jmbbm.2015.03.021 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jmbbm.2015.03.021 es_ES
dc.description.upvformatpinicio 60 es_ES
dc.description.upvformatpfin 69 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 48 es_ES
dc.relation.senia 292538 es_ES
dc.identifier.eissn 1878-0180
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES


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