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Describing the structural robustness landscape of bacterial small RNAs

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Describing the structural robustness landscape of bacterial small RNAs

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dc.contributor.author Rodrigo Tarrega, Guillermo es_ES
dc.contributor.author Fares Riaño, Mario Ali es_ES
dc.date.accessioned 2016-05-12T07:18:09Z
dc.date.available 2016-05-12T07:18:09Z
dc.date.issued 2012-04-13
dc.identifier.issn 1471-2148
dc.identifier.uri http://hdl.handle.net/10251/63944
dc.description.abstract Background: The potential role of RNA molecules as gene expression regulators has led to a new perspective on the intracellular control and genome organization. Because secondary structures are crucial for their regulatory role, we sought to investigate their robustness to mutations and environmental changes. Results: Here, we dissected the structural robustness landscape of the small non-coding RNAs (sncRNAs) encoded in the genome of the bacterium Escherichia coli. We found that bacterial sncRNAs are not significantly robust to both mutational and environmental perturbations when compared against artificial, unbiased sequences. However, we found that, on average, bacterial sncRNAs tend to be significantly plastic, and that mutational and environmental robustness strongly correlate. We further found that, on average, epistasis in bacterial sncRNAs is significantly antagonistic, and positively correlates with plasticity. Moreover, the evolution of robustness is likely dependent upon the environmental stability of the cell, with more fluctuating environments leading to the emergence and fixation of more robust molecules. Mutational robustness also appears to be correlated with structural functionality and complexity. Conclusion: Our study provides a deep characterization of the structural robustness landscape of bacterial sncRNAs, suggesting that evolvability could be evolved as a consequence of selection for more plastic molecules. It also supports that environmental fluctuations could promote mutational robustness. As a result, plasticity emerges to link robustness, functionality and evolvability. es_ES
dc.description.sponsorship We thank S. F. Elena for useful comments. G.R. is supported by an EMBO long-term fellowship co-funded by Marie Curie actions (ALTF-1177-2011). M.A.F. is supported by the Spanish Ministerio de Ciencia e Inovacion grant BFU2009-12022. en_EN
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation EMBO es_ES
dc.relation Marie Curie actions ALTF-1177-2011 es_ES
dc.relation Spanish Ministerio de Ciencia e Inovacion BFU2009-12022 es_ES
dc.relation.ispartof BMC Evolutionary Biology es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Plasticity es_ES
dc.subject Evolution es_ES
dc.subject Evolvability es_ES
dc.subject RNA structure es_ES
dc.subject Robustness es_ES
dc.subject Small RNA es_ES
dc.subject Thermodynamics es_ES
dc.title Describing the structural robustness landscape of bacterial small RNAs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/1471-2148-12-52
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Rodrigo Tarrega, G.; Fares Riaño, MA. (2012). Describing the structural robustness landscape of bacterial small RNAs. BMC Evolutionary Biology. 12(52):1-12. doi:10.1186/1471-2148-12-52 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/1471-2148-12-52 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 52 es_ES
dc.relation.senia 232781 es_ES
dc.identifier.pmid 22500888 en_EN
dc.identifier.pmcid PMC3368786 en_EN


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