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An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage

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An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage

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dc.contributor.author Vikingsson, Line Karina Alva es_ES
dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2016-05-16T16:26:22Z
dc.date.available 2016-05-16T16:26:22Z
dc.date.issued 2015-05-01
dc.identifier.issn 0021-9290
dc.identifier.uri http://hdl.handle.net/10251/64126
dc.description.abstract The aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly interconnected pores architecture. The scaffold compliance, stress strain response and hysteresis energy have been measured after different number of fatigue cycles, while the morphology has been observed by scanning electron microscopy at the same fatigue times. To simulate the growing tissue in the scaffold/tissue construct, the scaffold was filled with an aqueous solution of polyvinyl alcohol (PVA) and subjected to repeating cycles of freezing and thawing that increase the hydrogel stiffness. Fatigue studies show that the mechanical loading provokes failure of the dry scaffold at a smaller number of deformation cycles than when it is immersed in water, and also that 100,000 compressive dynamic cycles do not affect the scaffold/gel construct. This shows the stability of the scaffold implanted in a chondral defect and gives a realistic simulation of the mechanical performance from implantation of the empty scaffold to regeneration of the new tissue inside the scaffold's pores. es_ES
dc.description.sponsorship This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2013-46467-C4-1-R (including the FEDER financial support). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors acknowledge the assistance and advice of Electron Microscopy Service of the UPV en_EN
dc.language Español es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Journal of Biomechanics es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Tissue engineering es_ES
dc.subject Scaffolds es_ES
dc.subject Mechanical properties of biomaterials es_ES
dc.subject Fatigue prediction es_ES
dc.subject Cartilage regeneration es_ES
dc.subject Electron Microscopy Service of the UPV
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jbiomech.2015.02.013
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Vikingsson, LKA.; Gómez-Tejedor, JA.; Gallego Ferrer, G.; Gómez Ribelles, JL. (2015). An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage. Journal of Biomechanics. 48(7):1310-1317. https://doi.org/10.1016/j.jbiomech.2015.02.013 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jbiomech.2015.02.013 es_ES
dc.description.upvformatpinicio 1310 es_ES
dc.description.upvformatpfin 1317 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 48 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 289631 es_ES
dc.identifier.eissn 1873-2380
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES


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