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Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering

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Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering

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Nombre: Ródenas;Gómez;Lebourg ...
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dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Lebourg, Myriam Annette Madeleine es_ES
dc.date.accessioned 2016-05-17T07:32:24Z
dc.date.available 2016-05-17T07:32:24Z
dc.date.issued 2013-05
dc.identifier.issn 0957-4530
dc.identifier.uri http://hdl.handle.net/10251/64188
dc.description.abstract The aim of this work is to compare the effect of hydroxyapatite (HAp) or bioglass (BG) nanoparticles in a polycaprolactone composite scaffold aimed to bone regeneration. To allow a comparison of the influence of both types of fillers, scaffolds made of PCL or composites containing up to 20 % by weight HAp or BG were obtained. Scaffolds showed acceptable mechanical properties for its use and high interconnected porosity apt for cellular colonization. To study the effect of the different materials on pre-osteoblast cells differentiation, samples with 5 % mineral reinforcement, were cultured for up to 28 days in osteogenic medium. Cells proliferated in all scaffolds. Nevertheless, differentiation levels for the selected markers were higher in pure PCL scaffolds than in the composites; inclusion of bioactive particles showed no positive effects on cell differentiation. In osteogenic culture conditions, the presence of bioactive particles is thus not necessary in order to observe good differentiation. es_ES
dc.description.sponsorship JLGR acknowledges the support of the Spanish Ministry of Science and Education through project No. MAT2010-21611-C03-01 (including the FEDER financial support), and from Generalitat Valenciana, ACOMP/2012/075 Project.. Lebourg acknowledges the support of UPV through Project PAID-O6-10 and thanks CIBER-BBN for funding her post-doc research. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. J. Rodenas acknowledges the funding of his PhD by the Generalitat Valenciana through VALi+d Grant. The authors also wish to thank the microscopy service of Universidad Politecnica de Valencia as well as the confocal microscopy service of the Research Centre Principe Felipe for useful help and advice. en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag es_ES
dc.relation.ispartof Journal of Materials Science: Materials in Medicine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject OSTEOBLAST-LIKE CELLS es_ES
dc.subject IN-VITRO es_ES
dc.subject PROTEIN ADSORPTION es_ES
dc.subject BIOACTIVE GLASS es_ES
dc.subject MC3T3-E1 CELLS es_ES
dc.subject MATRIX MINERALIZATION es_ES
dc.subject NANO-HYDROXYAPATITE es_ES
dc.subject POROUS SCAFFOLDS es_ES
dc.subject DIFFERENTIATION; EXPRESSION es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification TERMODINAMICA APLICADA (UPV) es_ES
dc.title Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10856-013-4878-5
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2010-21611-C03-01/ES/MATERIALES BIOESTABLES Y BIOREABSORBIBLES A LARGO PLAZO COMO SOPORTES MACROPOROSOS PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACOMP%2F2012%2F075/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-06-10/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Ródenas Rochina, J.; Gómez Ribelles, JL.; Lebourg, MAM. (2013). Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering. Journal of Materials Science: Materials in Medicine. 24(5):1293-1308. https://doi.org/10.1007/s10856-013-4878-5 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s10856-013-4878-5 es_ES
dc.description.upvformatpinicio 1293 es_ES
dc.description.upvformatpfin 1308 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 260203 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
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