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Influence of the macro and micro-porous structure on the mechanical behavior of poly(L-lactic acid) scaffolds

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Influence of the macro and micro-porous structure on the mechanical behavior of poly(L-lactic acid) scaffolds

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dc.contributor.author Acosta Santamaria, V. es_ES
dc.contributor.author Deplaine, Harmony es_ES
dc.contributor.author Mariggio, D. es_ES
dc.contributor.author Villanueva Molines, Ana Rosalía es_ES
dc.contributor.author Garcia Aznar, Jose Manuel es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Doblare Castellano, Manuel es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.contributor.author Ochoa, I. es_ES
dc.date.accessioned 2016-05-17T07:33:05Z
dc.date.available 2016-05-17T07:33:05Z
dc.date.issued 2012-12-01
dc.identifier.issn 0022-3093
dc.identifier.uri http://hdl.handle.net/10251/64189
dc.description.abstract The development of macroporous biodegradable polymeric materials with three-dimensional pore structure is an important research field in tissue engineering. Structural scaffolds not only provide the cells with a mechanical support, but also perform an interactive physico-chemical role in tissue regeneration, thus it becomes important to be able to tune their mechanical properties to deliver appropriate mechanical signals to adhered cells for proper tissue regeneration. This work presents two series of poly(L-lactic acid) (PLLA) scaffolds in which we modulated the mechanical properties by systematically changing two synthesis parameters: polymer/solvent ratio and polymer-solution/porogen percentage. The peculiarity of the constructs is the presence of a double porosity: micropores generated by dioxane solvent using a freeze extraction technique and macropores produced by the leaching of macroporogen spheres. An increase in the PLLA/dioxane ratio decreases the micropores size and also influences to some extent the macropores size, due to the ability of dioxane to swell macroporogen particles. On the other hand, an increase in the amount of macroporogen increases the porosity by increasing the dimension of pore the throats connecting the macropores. Consequently, the increase in the PLLA/dioxane ratio produces a significant decrease in the permeability, and an increase in the apparent compression Young's modulus and aggregate modulus. When increasing the amount of macroporogen the permeability significantly increases and a decrease in the mechanical properties of the scaffolds is observed. Summarizing, with a systematic change of two fabrication parameters (amount of dioxane and macroporogen) the structural characteristics of the scaffolds were modulated and thereby their mechanical and transport properties were controlled. es_ES
dc.description.sponsorship The authors gratefully acknowledge research support from the Spanish Ministry of Science and Innovation through research project DPI2010-20399-C04-00. CIBER-BBN is an initiative funded by the VI National R&D&D&i Plan 2008-2011, Iniciativa Ingenio 2010, and Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Journal of Non-Crystalline Solids es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Poly(L-lactic es_ES
dc.subject Acid) es_ES
dc.subject Scaffold es_ES
dc.subject Design es_ES
dc.subject Freeze es_ES
dc.subject Extraction es_ES
dc.subject Compression es_ES
dc.subject Testing es_ES
dc.subject Tissue es_ES
dc.subject Engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Influence of the macro and micro-porous structure on the mechanical behavior of poly(L-lactic acid) scaffolds es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jnoncrysol.2012.08.001
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-03/ES/DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAFFOLD%2FSOPORTE PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-01/ES/DISEÑO, CONSTRUCCION Y VALIDACION DE UNA PLATAFORMA BIOMIMETICA PARA LA EVALUACION FUNCIONAL Y OPTIMIZACION DE CONSTRUCTOS DE INGENIERIA TISULAR DE CARTILAGO ARTICULAR/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Acosta Santamaria, V.; Deplaine, H.; Mariggio, D.; Villanueva Molines, AR.; Garcia Aznar, JM.; Gómez Ribelles, JL.; Doblare Castellano, M.... (2012). Influence of the macro and micro-porous structure on the mechanical behavior of poly(L-lactic acid) scaffolds. Journal of Non-Crystalline Solids. 358(23):3141-3149. https://doi.org/10.1016/j.jnoncrysol.2012.08.001 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jnoncrysol.2012.08.001 es_ES
dc.description.upvformatpinicio 3141 es_ES
dc.description.upvformatpfin 3149 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 358 es_ES
dc.description.issue 23 es_ES
dc.relation.senia 234074 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES


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