Ferrer Albero, A.; Sebastián Aguilar, R.; Sánchez Quintana, D.; Rodriguez, JF.; Godoy, EJ.; Martinez, L.; Saiz Rodríguez, FJ. (2015). Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation. PLoS ONE. 10(11):1-29. https://doi.org/10.1371/journal.pone.0141573
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/64804
Título:
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Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation
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Autor:
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Ferrer Albero, Ana
Sebastián Aguilar, Rafael
Sánchez Quintana, Damián
Rodriguez, José F.
Godoy, Eduardo Jorge
Martinez, Laura
Saiz Rodríguez, Francisco Javier
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Entidad UPV:
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Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà
Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
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Fecha difusión:
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Resumen:
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Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). ...[+]
Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which
combines a highly-detailed 3D atrial model and a torso model to study the relationship between atrial activation and surface signals in sinus rhythm. Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso. Our results also suggest that only nine regions (of the twenty-one structures in which the atrial surface was divided) make a significant contribution to the BSPM and determine the main P-wave characteristics.
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Palabras clave:
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BODY-SURFACE
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P-WAVE
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CONDUCTION-VELOCITY
,
SINUS RHYTHM
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ACTION-POTENTIALS
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VOLUME CONDUCTOR
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RATE-DEPENDENCE
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CANINE RIGHT
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HUMAN HEART
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FIBRILLATION
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Derechos de uso:
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Reserva de todos los derechos
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Fuente:
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PLoS ONE. (issn:
1932-6203
)
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DOI:
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10.1371/journal.pone.0141573
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Editorial:
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Public Library of Science
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Versión del editor:
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http://dx.doi.org/10.1371/journal.pone.0141573
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Código del Proyecto:
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info:eu-repo/grantAgreement/MINECO//TIN2014-59932-JIN/ES/CARACTERIZACION Y DIAGNOSTICO NO INVASIVO DE ARRITMIAS CARDIACAS MEDIANTE MODELADO COMPUTACIONAL 3D ANATOMO-FUNCIONAL DEL CORAZON Y TORSO HUMANO/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2012%2F030/ES/MEJORA EN LA PREVENCION Y TRATAMIENTO DE PATOLOGIAS CARDIACAS A TRAVES DE LA MODELIZACION MULTI-ESCALA Y LA SIMULACION COMPUTACIONAL (DIGITAL HEART)/
info:eu-repo/grantAgreement/MINECO//TIN2012-37546-C03-01/ES/CORAZON HUMANO COMPLETO FISIOLOGICO VIRTUAL: MEJORAS EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS ORIENTADO A PACIENTE/
"VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain
"Programa Estatal de Investigacion, Desarrollo e Innovacion Orientado a los Retos de la Sociedad" from the Ministerio de Economia y Competitividad
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Agradecimientos:
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This work was partially supported by the "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain and the European Commission (European ...[+]
This work was partially supported by the "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain and the European Commission (European Regional Development Funds - ERDF - FEDER), Award Number: TIN2012-37546-C03-01 (Recipient: Ana Ferrer); the "Programa Estatal de Investigacion, Desarrollo e Innovacion Orientado a los Retos de la Sociedad" from the Ministerio de Economia y Competitividad and the European Commission (European Regional Development Funds - ERDF - FEDER), Award Number: TIN2014-59932-JIN (Recipient: Rafael Sebastion); and the "Programa Prometeo" from the Generalitat Valenciana, Award Number: 2012/030 (Recipient: Laura Martinez).
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Tipo:
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Artículo
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