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Analysis of the prognostic value of soluble epidermal growth factor receptor plasma concentration in advanced non-small-cell lung cancer patients

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Analysis of the prognostic value of soluble epidermal growth factor receptor plasma concentration in advanced non-small-cell lung cancer patients

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dc.contributor.author Jantus Lewintre, Eloisa es_ES
dc.contributor.author Sirera Pérez, Rafael es_ES
dc.contributor.author Cabrera, Andrea es_ES
dc.contributor.author Blasco, Ana es_ES
dc.contributor.author Caballero, Cristina es_ES
dc.contributor.author Iranzo, Vega es_ES
dc.contributor.author Rosell, Rafael es_ES
dc.contributor.author Camps, Carlos es_ES
dc.date.accessioned 2016-06-01T11:49:44Z
dc.date.available 2016-06-01T11:49:44Z
dc.date.issued 2011-09
dc.identifier.issn 1525-7304
dc.identifier.uri http://hdl.handle.net/10251/65056
dc.description.abstract [EN] Background: Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial malignancies including lung cancer. A soluble fragment of the EGFR extracellular domain (sEGFR) can be detected in the blood of patients who have Non-small-cell lung cancer (NSCLC), but its clinical/ prognostic role must be further elucidated. Methods: sEGFR concentration was retrospectively determined by enzyme-linked immunosorbent assay in plasma samples from 308 advanced NSCLC patients (before treatment) and 109 healthy controls and correlated with clinico-pathological variables. Results: The concentration of sEGFR was lower in NSCLC patients than in controls (P <.0001). sEGFR behaves as a sensitive but not specific screening biomarker. No significant associations were observed between sEGFR concentration and demographic/clinical characteristics such as gender, Eastern Cooperative Oncology Group performance status, stage, and number or location of the metastatic sites. sEGFR was lower in patients with progressive disease or in squamous cell carcinoma compared with adenocarcinoma, but these differences were not significant. Patients with sEGFR ¿ 34.56 ng/mL showed a shorter overall survival (median 9.1 versus 12.2 months, P =.019) than others. Moreover, in multivariate analysis, sEGFR remained a significant independent prognostic marker. Conclusion: Low baseline sEGFR is associated with reduced survival in advanced NSCLC. Therefore, our findings in this large cohort of patients suggest that the determination of sEGFR concentration provides valuable prognostic information. © 2011 Elsevier Inc. All rights reserved. es_ES
dc.description.sponsorship This work was sponsored in part by a grant from the Spanish Society of Medical Oncology (SEOM) and by a grant (RD06/0020/1024) from Red Tematica de Investigacion Cooperativa en Cancer (RTICC), Instituto de Salud Carlos III (ISCIII), the Spanish Ministry of Science and Innovation and the European Regional Development Fund (ERDF) "Una manera de hacer Europa." The authors declare no conflicts of interest or any financial disclosure. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Spanish Society of Medical Oncology (SEOM) es_ES
dc.relation Red Tematica de Investigacion Cooperativa en Cancer (RTICC) RD06/0020/1024 es_ES
dc.relation Instituto de Salud Carlos III (ISCIII) es_ES
dc.relation Spanish Ministry of Science and Innovation es_ES
dc.relation European Regional Development Fund (ERDF) "Una manera de hacer Europa" es_ES
dc.relation.ispartof Clinical Lung Cancer es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biomarker es_ES
dc.subject EGFR prognostic es_ES
dc.subject NSCLC es_ES
dc.subject Cisplatin es_ES
dc.subject Docetaxel es_ES
dc.subject Epidermal growth factor receptor es_ES
dc.subject Erlotinib es_ES
dc.subject Gefitinib es_ES
dc.subject Adult es_ES
dc.subject Advanced cancer es_ES
dc.subject Aged es_ES
dc.subject Article es_ES
dc.subject Cancer combination chemotherapy es_ES
dc.subject Cancer growth es_ES
dc.subject Cancer localization es_ES
dc.subject Cancer patient es_ES
dc.subject Cancer survival es_ES
dc.subject Cohort analysis es_ES
dc.subject Controlled study es_ES
dc.subject Disease course es_ES
dc.subject Disease severity es_ES
dc.subject Distant metastasis es_ES
dc.subject Enzyme linked immunosorbent assay es_ES
dc.subject Female es_ES
dc.subject Functional status es_ES
dc.subject Gender es_ES
dc.subject Human es_ES
dc.subject Human tissue es_ES
dc.subject Large cell carcinoma es_ES
dc.subject Lung adenocarcinoma es_ES
dc.subject Lung metastasis es_ES
dc.subject Lung non small cell cancer es_ES
dc.subject Lung squamous cell carcinoma es_ES
dc.subject Major clinical study es_ES
dc.subject Male es_ES
dc.subject Multiple cycle treatment es_ES
dc.subject Overall survival es_ES
dc.subject Prognosis es_ES
dc.subject Protein blood level es_ES
dc.subject Receiver operating characteristic es_ES
dc.subject Retrospective study es_ES
dc.subject Sensitivity and specificity es_ES
dc.subject Survival time es_ES
dc.subject Adenocarcinoma es_ES
dc.subject Aged, 80 and over es_ES
dc.subject Carcinoma, Non-Small-Cell Lung es_ES
dc.subject Carcinoma, Squamous Cell es_ES
dc.subject Case-Control Studies es_ES
dc.subject Disease Progression es_ES
dc.subject Enzyme-Linked Immunosorbent Assay es_ES
dc.subject Humans es_ES
dc.subject Lung Neoplasms es_ES
dc.subject Middle Aged es_ES
dc.subject Multivariate Analysis es_ES
dc.subject Receptor, Epidermal Growth Factor es_ES
dc.subject Retrospective Studies es_ES
dc.subject Survival Rate es_ES
dc.subject Tumor Markers, Biological es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.title Analysis of the prognostic value of soluble epidermal growth factor receptor plasma concentration in advanced non-small-cell lung cancer patients es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.cllc.2011.03.031
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Jantus Lewintre, E.; Sirera Pérez, R.; Cabrera, A.; Blasco, A.; Caballero, C.; Iranzo, V.; Rosell, R.... (2011). Analysis of the prognostic value of soluble epidermal growth factor receptor plasma concentration in advanced non-small-cell lung cancer patients. Clinical Lung Cancer. 12(5):320-327. doi:10.1016/j.cllc.2011.03.031 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion https://dx.doi.org/10.1016/j.cllc.2011.03.031 es_ES
dc.description.upvformatpinicio 320 es_ES
dc.description.upvformatpfin 327 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 220984 es_ES


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