Saso, S.; Petts, G.; David, AL.; Thum, M.; Chatterjee, J.; Vicente Antón, JS.; Marco Jiménez, F.... (2015). Achieving an early pregnancy following allogeneic uterine transplantation in a rabbit model. European Journal of Obstetrics and Gynecology and Reproductive Biology. (185):164-169. doi:10.1016/j.ejogrb.2014.12.017
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/65122
Title:
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Achieving an early pregnancy following allogeneic uterine transplantation in a rabbit model
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Author:
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Saso, Srdjan
Petts, Gemma
David, Anna L.
Thum, Meen-Yau
Chatterjee, Jayanta
Vicente Antón, José Salvador
Marco Jiménez, Francisco
Corless, David
Boyd, Michael
Noakes, David
Lindsay, Iain
Del Priorei, Giuseppe
Ghaem-Maghami, Sadaf
Smith, J. Richard
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UPV Unit:
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Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal
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Issued date:
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Abstract:
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[EN] Objective: Uterine transplantation (UTx) has been proposed as a treatment option for women diagnosed
with absolute uterine factor infertility (AUFI). The goal of UTx remains achieving pregnancy and live
birth of ...[+]
[EN] Objective: Uterine transplantation (UTx) has been proposed as a treatment option for women diagnosed
with absolute uterine factor infertility (AUFI). The goal of UTx remains achieving pregnancy and live
birth of a healthy neonate following allogeneic UTx. Our aim was to assess whether fertility was possible
following allogeneic uterine transplantation (UTx), when the recipient had demonstrated long-term
survival and had been administered immunosuppression.
Study design: Nine allogeneic UTx in New Zealand White rabbits were performed using a pre-determined
protocol. Tacrolimus was the immunosuppressant selected. Embryos were transferred into both cornua
of the sole living recipient via a mini-midline laparotomy. The pregnancy was monitored with regular
reproductive profiles and serial trans-abdominal ultrasound to measure conceptus growth (gestation sac
and crown rump length (CRL)).
Results: In the sole surviving doe a gestation sac was visualised on ultrasound from Day 9 (D9) after
embryo transfer. Gestation sac diameter and CRL increased from D9 to D16 but by D18 the gestation sac
had reduced in size. The fetus was no longer visible, suggesting fetal resorption had occurred.
Subsequent scans on D22 and D25 did not demonstrate a gestation sac. Scheduled necropsy on D27 and
histopathology confirmed evidence of a gravid uterus and presence of a gestational sac. A single episode
of acute rejection occurred on D13.
Conclusion: Pregnancy was achieved after rabbit allogeneic UTx but serial ultrasound suggested that
fetal demise occurred prior to scheduled necropsy. The study represents only the third example of
conception and pregnancy following an animal allogeneic UTx.
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Subjects:
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Fertility
,
Uterine transplantation
,
Rabbit
,
Pregnancy
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Copyrigths:
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Reserva de todos los derechos
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Source:
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European Journal of Obstetrics and Gynecology and Reproductive Biology. (issn:
0301-2115
) (eissn:
1872-7654
)
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DOI:
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10.1016/j.ejogrb.2014.12.017
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Publisher:
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Elsevier
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Publisher version:
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https://dx.doi.org/10.1016/j.ejogrb.2014.12.017
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Project ID:
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UCLH/UCL via the Department of Health's NIHR Biomedical Research Centres
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Thanks:
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The authors would like to thank all the staff and veterinarians at the Royal Veterinary College (London, UK) who have been with us from the beginning and have worked tirelessly at ensuring we had the best possible conditions ...[+]
The authors would like to thank all the staff and veterinarians at the Royal Veterinary College (London, UK) who have been with us from the beginning and have worked tirelessly at ensuring we had the best possible conditions to carry out our transplant work. ALD receives funding at UCLH/UCL via the Department of Health's NIHR Biomedical Research Centres funding scheme.
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Type:
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Artículo
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