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Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution

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Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution

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dc.contributor.author Zwart, Mark Peter es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2016-06-14T07:45:44Z
dc.date.available 2016-06-14T07:45:44Z
dc.date.issued 2015
dc.identifier.issn 2327-056X
dc.identifier.uri http://hdl.handle.net/10251/65835
dc.description.abstract For virus infections of multicellular hosts, narrow genetic bottlenecks during transmission and within-host spread appear to be widespread. These bottlenecks will affect the maintenance of genetic variation in a virus population and the prevalence of mixed-strain infections, thereby ultimately determining the strength with which different random forces act during evolution. Here we consider different approaches for estimating bottleneck sizes and weigh their merits. We then review quantitative estimates of bottleneck size during cellular infection, within-host spread, horizontal transmission, and finally vertical transmission. In most cases we find that bottlenecks do regularly occur, although in many cases they appear to be virion-concentration dependent. Finally, we consider the evolutionary implications of genetic bottlenecks during virus infection. Although on average strong bottlenecks will lead to declines in fitness, we consider a number of scenarios in which bottlenecks could also be advantageous for viruses. es_ES
dc.language Inglés es_ES
dc.publisher Annual Reviews es_ES
dc.relation.ispartof Annual Review of Virology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Genetic random drift es_ES
dc.subject Genetic variability es_ES
dc.subject Horizontal transmission es_ES
dc.subject Independent action hypothesis es_ES
dc.subject Vertical transmission es_ES
dc.subject Virus evolution es_ES
dc.title Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1146/annurev-virology-100114-055135
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Zwart, MP.; Elena Fito, SF. (2015). Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution. Annual Review of Virology. 2:161-179. doi:10.1146/annurev-virology-100114-055135 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1146/annurev-virology-100114-055135 es_ES
dc.description.upvformatpinicio 161 es_ES
dc.description.upvformatpfin 179 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 2 es_ES
dc.relation.senia 310112 es_ES


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