- -

Dynamics of alternative modes of RNA replication for positive-sense RNA viruses

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Dynamics of alternative modes of RNA replication for positive-sense RNA viruses

Show simple item record

Files in this item

dc.contributor.author Sardanyes Cayuela, Jose es_ES
dc.contributor.author Martinez, Fernando es_ES
dc.contributor.author Daros Arnau, Jose Antonio es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2016-06-20T10:52:15Z
dc.date.available 2016-06-20T10:52:15Z
dc.date.issued 2012-04-07
dc.identifier.issn 1742-5689
dc.identifier.uri http://hdl.handle.net/10251/66167
dc.description.abstract [EN] We propose and study nonlinear mathematical models describing the intracellular time dynamics of viral RNA accumulation for positive-sense single-stranded RNA viruses. Our models consider different replication modes ranging between two extremes represented by the geometric replication (GR) and the linear stamping machine replication (SMR). We first analyse a model that quantitatively reproduced experimental data for the accumulation dynamics of both polarities of turnip mosaic potyvirus RNAs. We identify a non-degenerate transcritical bifurcation governing the extinction of both strands depending on three key parameters: the mode of replication (a), the replication rate (r) and the degradation rate (d) of viral strands. Our results indicate that the bifurcation associated with a generically takes place when the replication mode is closer to the SMR, thus suggesting that GR may provide viral strands with an increased robustness against degradation. This transcritical bifurcation, which is responsible for the switching from an active to an absorbing regime, suggests a smooth (i.e. secondorder), absorbing-state phase transition. Finally, we also analyse a simplified model that only incorporates asymmetry in replication tied to differential replication modes. es_ES
dc.description.sponsorship This work was funded by the Human Frontier Science Program Organization grant RGP12/2008, by the Spanish Ministerio de Ciencia e Innovacion grants BIO2008-01986 (J.A.D.) and BFU2009-06993 (S.F.E.) and by the Santa Fe Institute. F. M. is the recipient of a predoctoral fellowship from Universitat Politecnica de Valencia. We also thank the hospitality and support of the Kavli Institute for Theoretical Physics (University of California at Santa Barbara), where part of this work was developed (grant NSF PHY05-51164).
dc.language Inglés es_ES
dc.publisher Royal Society, The es_ES
dc.relation HFSPRGP12/2008 es_ES
dc.relation MICINN/BIO2008-01986 es_ES
dc.relation MICINN/BFU2009-06993 es_ES
dc.relation NSF/NSF PHY05-51164 es_ES
dc.relation.ispartof Journal of the Royal Society. Interface es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Complex systems es_ES
dc.subject Intracellular viral dynamics es_ES
dc.subject Nonlinear dynamics es_ES
dc.subject Replication mode es_ES
dc.subject RNA viruses es_ES
dc.subject Systems biology es_ES
dc.title Dynamics of alternative modes of RNA replication for positive-sense RNA viruses es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1098/rsif.2011.0471
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
dc.description.bibliographicCitation Sardanyes Cayuela, J.; Martinez, F.; Daros Arnau, JA.; Elena Fito, SF. (2012). Dynamics of alternative modes of RNA replication for positive-sense RNA viruses. Journal of the Royal Society. Interface. 9(69):768-776. doi:10.1098/rsif.2011.0471 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1098/rsif.2011.0471 es_ES
dc.description.upvformatpinicio 768 es_ES
dc.description.upvformatpfin 776 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 69 es_ES
dc.relation.senia 216051 es_ES
dc.identifier.eissn 1742-5662
dc.identifier.pmcid PMC3284139 en_EN
dc.identifier.pmcid PMC3176287 en_EN
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Human Frontier Science Program Organization
dc.contributor.funder National Science Foundation, EEUU


This item appears in the following Collection(s)

Show simple item record