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dc.contributor.author | Locascio, Antonella Anna Maria | es_ES |
dc.contributor.author | Blazquez Rodriguez, Miguel Angel | es_ES |
dc.contributor.author | Alabadí Diego, David | es_ES |
dc.date.accessioned | 2016-06-24T10:04:47Z | |
dc.date.issued | 2013-05-06 | |
dc.identifier.issn | 0960-9822 | |
dc.identifier.uri | http://hdl.handle.net/10251/66422 | |
dc.description.abstract | Plant morphogenesis relies on specific patterns of cell division and expansion. It is well established that cortical microtubules influence the direction of cell expansion [1, 2], but less is known about the molecular mechanisms that regulate microtubule arrangement. Here we show that the phytohormones gibberellins (GAs) regulate microtubule orientation through physical interaction between the nuclear-localized DELLA proteins and the prefoldin complex, a cochaperone required for tubulin folding [3]. In the presence of GA, DELLA proteins are degraded, and the prefoldin complex stays in the cytoplasm and is functional. In the absence of GA, the prefoldin complex is localized to the nucleus, which severely compromises a/b-tubulin heterodimer availability, affecting microtubule organization. The physiological relevance of this molecular mechanism was confirmed by the observation that the daily rhythm of plant growth was accompanied by coordinated oscillation of DELLA accumulation, prefoldin subcellular localization, and cortical microtubule reorientation. | es_ES |
dc.description.sponsorship | We thank C. Somerville and Y. Gu for the PFD6-YFP line, J. Salinas for the pfd5 mutant, N. Mann de la Rosa for the myc-GAI construct, and A. Ferrando for the BiFC vectors. We also thank S. Tarraga for assistance with the gel filtration assays and C. Fankhauser, J. Salinas, and P. Rodriguez for discussions and critical reading of the manuscript. This work was supported by grants from the Spanish Ministry of Science and Innovation (BIO2010-15071 and CSD2007-00057) and the Generalitat Valenciana (ACOMP/2011/288 and PROMETEO/2010/020). A.L. was funded during part of her work by Fondo per gli Investimenti della Ricerca di Base of the Italian Ministry of Education, the University, and Research (MIUR). | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier (Cell Press) | es_ES |
dc.relation.ispartof | Current Biology | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.title | Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction | es_ES |
dc.type | Artículo | es_ES |
dc.embargo.lift | 10000-01-01 | |
dc.embargo.terms | forever | es_ES |
dc.identifier.doi | 10.1016/j.cub.2013.03.053 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//CSD2007-00057/ES/Función y potencial biotecnológico de los factores de transcripción de las plantas./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F020/ES/Identificación de nuevos fármacos con potencia potencial uso biotecnológico en cultivos mediante un abordaje de genética química/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//ACOMP%2F2011%2F288/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BIO2010-15071/ES/SEÑALIZACION POR GIBERELINAS DEPENDIENTE DEL CONTEXTO EN ARABIDOPSIS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Locascio, AAM.; Blazquez Rodriguez, MA.; Alabadí Diego, D. (2013). Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction. Current Biology. 23:804-809. https://doi.org/10.1016/j.cub.2013.03.053 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.cub.2013.03.053 | es_ES |
dc.description.upvformatpinicio | 804 | es_ES |
dc.description.upvformatpfin | 809 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 23 | es_ES |
dc.relation.senia | 259556 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministero dell'Istruzione dell'Università e della Ricerca, Italia | es_ES |