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dc.contributor.author | de Pereda Sebastián, Diego![]() |
es_ES |
dc.contributor.author | Romero Vivó, Sergio![]() |
es_ES |
dc.contributor.author | Ricarte Benedito, Beatriz![]() |
es_ES |
dc.contributor.author | Rossetti, Paolo![]() |
es_ES |
dc.contributor.author | Ampudia Blasco, Francisco Javier![]() |
es_ES |
dc.contributor.author | Bondía Company, Jorge![]() |
es_ES |
dc.date.accessioned | 2016-06-28T16:56:22Z | |
dc.date.available | 2016-06-28T16:56:22Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1025-5842 | |
dc.identifier.uri | http://hdl.handle.net/10251/66699 | |
dc.description.abstract | Continuous glucose monitors can measure interstitial glucose concentration in real time for closed-loop glucose control systems, known as artificial pancreas. These control systems use an insulin feedback to maintain plasma glucose concentration within a narrow and safe range, and thus to avoid health complications. As it is not possible to measure plasma insulin concentration in real time, insulin models have been used in literature to estimate them. Nevertheless, the significant interand intra-patient variability of insulin absorption jeopardizes the accuracy of these estimations. In order to reduce these limitations, our objective is to perform a real-time estimation of plasma insulin concentration from continuous glucose monitoring (CGM). Hovorka s glucose insulin model has been incorporated in an extended Kalman filter in which different selected time-variant model parameters have been considered as extended states. The observability of the original Hovorka s model and of several extended models has been evaluated by their Lie derivatives. We have evaluated this methodology with an in-silico study with 100 patients with Type 1 diabetes during 25 h. Furthermore, it has been also validated using clinical data from 12 insulin pump patients with Type 1 diabetes who underwent four mixed meal studies. Real-time insulin estimations have been compared to plasma insulin measurements to assess performance showing the validity of the methodology here used in comparison with that formerly used for insulin models. Hence, real-time estimations for plasma insulin concentration based on subcutaneous glucose monitoring can be beneficial for increasing the efficiency of control algorithms for the artificial pancreas. | es_ES |
dc.description.sponsorship | This work was partially supported by the Spanish Ministerio de Ciencia e Innovacion through Grant DPI-2010-20764-C02-01 and Grant DPI-2013-46982-C2-1-R, and the European Union through FEDER fund. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Taylor & Francis | es_ES |
dc.relation.ispartof | Computer Methods in Biomechanics and Biomedical Engineering | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Extended Kalman filter | es_ES |
dc.subject | Insulin estimation | es_ES |
dc.subject | Glucose insulin models | es_ES |
dc.subject | Type 1 diabetes | es_ES |
dc.subject | Artificial pancreas | es_ES |
dc.subject.classification | INGENIERIA DE SISTEMAS Y AUTOMATICA | es_ES |
dc.subject.classification | MATEMATICA APLICADA | es_ES |
dc.title | Real-time estimation of plasma insulin concentration from continuous glucose monitor measurements | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1080/10255842.2015.1077234 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//DPI2010-20764-C02-01/ES/NUEVAS ESTRATEGIAS DE CONTROL GLUCEMICO POSTPRANDIAL MEDIANTE TERAPIA CON BOMBA DE INSULINA EN DIABETES TIPO 1/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//DPI2013-46982-C2-1-R/ES/NUEVOS METODOS PARA LA EFICIENCIA Y SEGURIDAD DEL PANCREAS ARTIFICIAL DOMICILIARIO EN DIABETES TIPO 1/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica | es_ES |
dc.description.bibliographicCitation | De Pereda Sebastián, D.; Romero Vivó, S.; Ricarte Benedito, B.; Rossetti, P.; Ampudia Blasco, FJ.; Bondía Company, J. (2015). Real-time estimation of plasma insulin concentration from continuous glucose monitor measurements. Computer Methods in Biomechanics and Biomedical Engineering. Sep:1-9. https://doi.org/10.1080/10255842.2015.1077234 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1080/10255842.2015.1077234 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 9 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | Sep | es_ES |
dc.relation.senia | 302633 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |