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Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice

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Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice

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dc.contributor.author Andújar Pérez, Isabel es_ES
dc.contributor.author Rios, José Luis es_ES
dc.contributor.author Giner, Rosa María es_ES
dc.contributor.author Cerda, José Miguel es_ES
dc.contributor.author Recio, María del Carmen es_ES
dc.date.accessioned 2016-07-01T11:57:08Z
dc.date.available 2016-07-01T11:57:08Z
dc.date.issued 2012
dc.identifier.issn 1741-427X
dc.identifier.uri http://hdl.handle.net/10251/66924
dc.description.abstract [EN] The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an anti-inflammatory agent in the treatment of ulcerative colitis (UC). Acute UC was induced in Balb/C mice by oral administration of 5% dextran sodium sulfate (DSS). The disease activity index was evaluated, and a histologic study was carried out. Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools. The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the myeloperoxidase activity. The expression of cyclooxygenase-2 was reduced by 75%, activation of NF-kappa B was reduced by 44%, and that of pSTAT-3 by 47%, as well as TNF-alpha, IL-1 beta, and IL-6 production. Similar results were obtained in primary macrophages culture. This is the first report of shikonin's ability to attenuate acute UC induced by DSS. Shikonin acts by blocking the activation of two major targets: NF-kappa B and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease. es_ES
dc.description.sponsorship This work was supported by the Spanish Government (SAF2009-13059-C03-01). I. Andujar is grateful for a fellowship from the Generalitat Valenciana, Grant BFPI/2008/040.
dc.language Inglés es_ES
dc.publisher Hindawi Publishing Corporation es_ES
dc.relation MICINN/SAF2009-13059-C03-01 es_ES
dc.relation GV/BFPI/2008/040 es_ES
dc.relation.ispartof Evidence-Based Complementary and Alternative Medicine es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Inflammatory-bowel-disease es_ES
dc.subject NF-KAPPA-B es_ES
dc.subject Experimental Murine Colitis es_ES
dc.subject Acid-induced colitis es_ES
dc.subject Ulcerative-colitis es_ES
dc.subject Polymorphonuclear leukocytes es_ES
dc.subject Antisense oligonucleotide es_ES
dc.subject Intestinal inflammation es_ES
dc.subject Activation es_ES
dc.subject Cytokines es_ES
dc.title Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1155/2012/271606
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Conservación y Mejora de la Agrodiversidad Valenciana - Institut Universitari de Conservació i Millora de l'Agrodiversitat Valenciana es_ES
dc.description.bibliographicCitation Andújar Pérez, I.; Rios, JL.; Giner, RM.; Cerda, JM.; Recio, MDC. (2012). Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice. Evidence-Based Complementary and Alternative Medicine. 271606:1-15. doi:10.1155/2012/271606 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1155/2012/271606 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 15 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 271606 es_ES
dc.relation.senia 238292 es_ES
dc.identifier.pmid 23346196
dc.identifier.pmcid PMC3549420 en_EN
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Ministerio de Ciencia e Innovación


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