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dc.contributor.author | Hillung, Julia | es_ES |
dc.contributor.author | Cuevas Torrijos, Jose Manuel | es_ES |
dc.contributor.author | Valverde, Sergi | es_ES |
dc.contributor.author | Elena Fito, Santiago Fco | es_ES |
dc.date.accessioned | 2016-07-13T09:45:16Z | |
dc.date.available | 2016-07-13T09:45:16Z | |
dc.date.issued | 2014-09 | |
dc.identifier.issn | 0014-3820 | |
dc.identifier.uri | http://hdl.handle.net/10251/67535 | |
dc.description.abstract | [EN] This study evaluates the extent to which genetic differences among host individuals from the same species condition the evolution of a plant RNA virus. We performed a threefold replicated evolution experiment in which Tobacco etch potyvirus isolate At17b (TEV-At17b), adapted to Arabidopsis thaliana ecotype Ler-0, was serially passaged in five genetically heterogeneous ecotypes of A. thaliana. After 15 passages we found that evolved viruses improved their fitness, showed higher infectivity and stronger virulence in their local host ecotypes. The genome of evolved lineages was sequenced and putative adaptive mutations identified. Host-driven convergent mutations have been identified. Evidences supported selection for increased translational efficiency. Next, we sought for the specificity of virus adaptation by infecting all five ecotypes with all 15 evolved virus populations. We found that some ecotypes were more permissive to infection than others, and that some evolved virus isolates were more specialist/generalist than others. The bipartite network linking ecotypes with evolved viruses was significantly nested but not modular, suggesting that hard-to-infect ecotypes were infected by generalist viruses whereas easy-to-infect ecotypes were infected by all viruses, as predicted by a gene-for-gene model of infection. | es_ES |
dc.description.sponsorship | The authors thank Francisca de la Iglesia and Paula Agudo for excellent technical assistance. We acknowledge grant BFU2012-30805 from the Spanish Ministerio de Economia y Competitividad to SFE. JMC was supported by a JAE-doc contract from CSIC. JH was supported by a pre-doctoral fellowship from Ministerio de Economia y Competitividad. | |
dc.language | Inglés | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.ispartof | Evolution | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Emerging viruses | es_ES |
dc.subject | Experimental evolution | es_ES |
dc.subject | Generalists | es_ES |
dc.subject | Specialists | es_ES |
dc.subject | Virus evolution | es_ES |
dc.title | Experimental evolution of an emerging plant virus in host genotypes that differ in their susceptibility to infection | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1111/evo.12458 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BFU2012-30805/ES/EVOLUTIONARY SYSTEMS VIROLOGY: EPISTASIS AND THE RUGGEDNESS OF ADAPTIVE LANDSCAPES, MUTATIONS IN REGULATORY SEQUENCES, AND THE HOST DETERMINANTS OF VIRAL FITNESS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Hillung, J.; Cuevas Torrijos, JM.; Valverde, S.; Elena Fito, SF. (2014). Experimental evolution of an emerging plant virus in host genotypes that differ in their susceptibility to infection. Evolution. 68(9):2467-2480. https://doi.org/10.1111/evo.12458 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1111/evo.12458 | es_ES |
dc.description.upvformatpinicio | 2467 | es_ES |
dc.description.upvformatpfin | 2480 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 68 | es_ES |
dc.description.issue | 9 | es_ES |
dc.relation.senia | 280718 | es_ES |
dc.identifier.pmid | 24889935 | |
dc.contributor.funder | Ministerio de Economía y Competitividad |