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RNA virus genetic robustness: possible causes and some consequences.

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RNA virus genetic robustness: possible causes and some consequences.

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dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2016-09-20T10:17:53Z
dc.date.available 2016-09-20T10:17:53Z
dc.date.issued 2012-10
dc.identifier.issn 1879-6257
dc.identifier.uri http://hdl.handle.net/10251/70146
dc.description.abstract [EN] In general terms, robustness is the capacity of biological systems to function in spite of genetic or environmental perturbations. The small and compacted genomes and high mutation rates of RNA viruses, as well as the ever-changing environments wherein they replicate, create the conditions for robustness to be advantageous. In this review, I will enumerate possible mechanisms by which viral populations may acquire robustness, distinguishing between mechanisms that are inherent to virus replication and population dynamics and those that result from the interaction with host factors. Then, I will move to review some evidences that RNA virus populations are robust indeed. Finally, I will comment on the implications of robustness for virus evolvability, the emergence of new viruses and the efficiency of lethal mutagenesis as an antiviral strategy es_ES
dc.description.sponsorship This work was supported by the Spanish MICINN grant BFU2009-06993 and by the Santa Fe Institute. I thank Mark P. Zwart for critical reading of the manuscript.
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation MICINN/BFU2009-06993 es_ES
dc.relation Santa Fe Institute es_ES
dc.relation.ispartof Current Opinion in Virology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.title RNA virus genetic robustness: possible causes and some consequences. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.coviro.2012.06.008
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Elena Fito, SF. (2012). RNA virus genetic robustness: possible causes and some consequences. Current Opinion in Virology. 2(5):525-530. doi:10.1016/j.coviro.2012.06.008 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.coviro.2012.06.008 es_ES
dc.description.upvformatpinicio 525 es_ES
dc.description.upvformatpfin 530 es_ES
dc.type.version info:eu repo/semantics/publishedVersion es_ES
dc.description.volume 2 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 233118 es_ES
dc.identifier.pmid 22818515
dc.contributor.funder Ministerio de Ciencia e Innovación


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