dc.contributor.author |
Vera Sirera, Francisco José
|
es_ES |
dc.contributor.author |
De Rybel, B
|
es_ES |
dc.contributor.author |
Urbez Lagunas, Cristina
|
es_ES |
dc.contributor.author |
Kouklas, E
|
es_ES |
dc.contributor.author |
Pesquera, M
|
es_ES |
dc.contributor.author |
Álvarez Mahecha, Juan Camilo
|
es_ES |
dc.contributor.author |
Minguet, E.G.
|
es_ES |
dc.contributor.author |
Tuominen, H
|
es_ES |
dc.contributor.author |
Carbonell Gisbert, Juan
|
es_ES |
dc.contributor.author |
Borst, JW
|
es_ES |
dc.contributor.author |
Weijers, D
|
es_ES |
dc.contributor.author |
Blazquez Rodriguez, Miguel Angel
|
es_ES |
dc.date.accessioned |
2016-09-28T06:51:49Z |
|
dc.date.issued |
2015-11-23 |
|
dc.identifier.issn |
1534-5807 |
|
dc.identifier.uri |
http://hdl.handle.net/10251/70531 |
|
dc.description.abstract |
Control of tissue dimensions in multicellular organisms requires the precise quantitative regulation of mitotic activity. In plants, where cells are immobile, tissue size is achieved through control of both cell division orientation and mitotic rate. The bHLH transcription factor heterodimer formed by TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHVV) is a central regulator of vascular width-increasing divisions. An important unanswered question is how its activity is limited to specify vascular tissue dimensions. Here we identify a regulatory network that restricts TMO5/LHW activity. We show that thermospermine synthase ACAULIS5 antagonizes TMO5/LHW activity by promoting the accumulation of SAC51-LIKE (SACL) bHLH transcription factors. SACL proteins heterodimerize with LHW therefore likely competing with TMO5/LHW interactions prevent activation of TMO5/LHW target genes, and suppress the over-proliferation caused by excess TMO5/LHW activity. These findings connect two thus-far disparate pathways and provide a mechanistic understanding of the quantitative control of vascular tissue growth. |
es_ES |
dc.description.sponsorship |
The authors would like to thank the genetic mapping facility at Miguel Hernandez University (Elche) run by Jose L. Micol and Maria Rosa Ponce and the microscopy service of the Universidad Politecnica of Valencia. We also thank J. Agusti, D. Alabadi, D. Esteve, C. Ferrandiz, M. de Lucas, and F. Madueno for discussions and critical reading of the manuscript. B.D.R. was funded by long-term FEBS and Marie Curie (IEF-2009-252503) Fellowships, the Netherlands Organization for Scientific Research (NWO VIDI 864.13.001), and by the Research Foundation Flanders (FWO G0D0515N and 12D1815N). D.W. was funded by the Netherlands Organization for Scientific Research (ERA-CAPS project EURO-PEC, 849.13.006) and the European Research Council (Starting Grant "CELLPATTERN," contract no. 281573). M.P. was funded by La Caixa fellowship. J.C. was the recipient of grant BIO2011-23828 from the Spanish Ministry of Science and Innovation. |
en_EN |
dc.language |
Inglés |
es_ES |
dc.publisher |
Elsevier (Cell Press) |
es_ES |
dc.relation.ispartof |
Developmental Cell |
es_ES |
dc.rights |
Reserva de todos los derechos |
es_ES |
dc.title |
A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants |
es_ES |
dc.type |
Artículo |
es_ES |
dc.embargo.lift |
10000-01-01 |
|
dc.embargo.terms |
forever |
es_ES |
dc.identifier.doi |
10.1016/j.devcel.2015.10.022 |
|
dc.relation.projectID |
info:eu-repo/grantAgreement/FWO//G0D0515N/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/EC/FP7/281573/EU/The Cellular Basis of Multicellular Pattern Formation/ |
|
dc.relation.projectID |
info:eu-repo/grantAgreement/NWO//849.13.006/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/EC/FP7/252503/EU/The role of bHLH transcription factors during embryo root initiation/ |
|
dc.relation.projectID |
info:eu-repo/grantAgreement/NWO//864.13.001/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/FWO//12D1815N/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/MICINN//BIO2011-23828/ES/CONTROL DE LA DIFERENCIACION DEL XILEMA POR LOS FACTORES DE TRANSCRIPCION AJAX/ |
es_ES |
dc.rights.accessRights |
Cerrado |
es_ES |
dc.contributor.affiliation |
Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes |
es_ES |
dc.description.bibliographicCitation |
Vera Sirera, FJ.; De Rybel, B.; Urbez Lagunas, C.; Kouklas, E.; Pesquera, M.; Álvarez Mahecha, JC.; Minguet, E.... (2015). A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants. Developmental Cell. 35(4):432-443. https://doi.org/10.1016/j.devcel.2015.10.022 |
es_ES |
dc.description.accrualMethod |
S |
es_ES |
dc.relation.publisherversion |
http://dx.doi.org/10.1016/j.devcel.2015.10.022 |
es_ES |
dc.description.upvformatpinicio |
432 |
es_ES |
dc.description.upvformatpfin |
443 |
es_ES |
dc.type.version |
info:eu-repo/semantics/publishedVersion |
es_ES |
dc.description.volume |
35 |
es_ES |
dc.description.issue |
4 |
es_ES |
dc.relation.senia |
306404 |
es_ES |
dc.contributor.funder |
Ministerio de Ciencia e Innovación |
es_ES |
dc.contributor.funder |
Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona |
es_ES |
dc.contributor.funder |
Netherlands Organization for Scientific Research |
es_ES |
dc.contributor.funder |
Agencia Estatal de Investigación |
es_ES |
dc.contributor.funder |
European Commission |
|