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A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants

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A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants

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dc.contributor.author Vera Sirera, Francisco José es_ES
dc.contributor.author De Rybel, B es_ES
dc.contributor.author Urbez Lagunas, Cristina es_ES
dc.contributor.author Kouklas, E es_ES
dc.contributor.author Pesquera, M es_ES
dc.contributor.author Álvarez Mahecha, Juan Camilo es_ES
dc.contributor.author Minguet, E.G. es_ES
dc.contributor.author Tuominen, H es_ES
dc.contributor.author Carbonell Gisbert, Juan es_ES
dc.contributor.author Borst, JW es_ES
dc.contributor.author Weijers, D es_ES
dc.contributor.author Blazquez Rodriguez, Miguel Angel es_ES
dc.date.accessioned 2016-09-28T06:51:49Z
dc.date.issued 2015-11-23
dc.identifier.issn 1534-5807
dc.identifier.uri http://hdl.handle.net/10251/70531
dc.description.abstract Control of tissue dimensions in multicellular organisms requires the precise quantitative regulation of mitotic activity. In plants, where cells are immobile, tissue size is achieved through control of both cell division orientation and mitotic rate. The bHLH transcription factor heterodimer formed by TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHVV) is a central regulator of vascular width-increasing divisions. An important unanswered question is how its activity is limited to specify vascular tissue dimensions. Here we identify a regulatory network that restricts TMO5/LHW activity. We show that thermospermine synthase ACAULIS5 antagonizes TMO5/LHW activity by promoting the accumulation of SAC51-LIKE (SACL) bHLH transcription factors. SACL proteins heterodimerize with LHW therefore likely competing with TMO5/LHW interactions prevent activation of TMO5/LHW target genes, and suppress the over-proliferation caused by excess TMO5/LHW activity. These findings connect two thus-far disparate pathways and provide a mechanistic understanding of the quantitative control of vascular tissue growth. es_ES
dc.description.sponsorship The authors would like to thank the genetic mapping facility at Miguel Hernandez University (Elche) run by Jose L. Micol and Maria Rosa Ponce and the microscopy service of the Universidad Politecnica of Valencia. We also thank J. Agusti, D. Alabadi, D. Esteve, C. Ferrandiz, M. de Lucas, and F. Madueno for discussions and critical reading of the manuscript. B.D.R. was funded by long-term FEBS and Marie Curie (IEF-2009-252503) Fellowships, the Netherlands Organization for Scientific Research (NWO VIDI 864.13.001), and by the Research Foundation Flanders (FWO G0D0515N and 12D1815N). D.W. was funded by the Netherlands Organization for Scientific Research (ERA-CAPS project EURO-PEC, 849.13.006) and the European Research Council (Starting Grant "CELLPATTERN," contract no. 281573). M.P. was funded by La Caixa fellowship. J.C. was the recipient of grant BIO2011-23828 from the Spanish Ministry of Science and Innovation. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier (Cell Press) es_ES
dc.relation.ispartof Developmental Cell es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1016/j.devcel.2015.10.022
dc.relation.projectID info:eu-repo/grantAgreement/FWO//G0D0515N/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/281573/EU/The Cellular Basis of Multicellular Pattern Formation/
dc.relation.projectID info:eu-repo/grantAgreement/NWO//849.13.006/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/252503/EU/The role of bHLH transcription factors during embryo root initiation/
dc.relation.projectID info:eu-repo/grantAgreement/NWO//864.13.001/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FWO//12D1815N/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BIO2011-23828/ES/CONTROL DE LA DIFERENCIACION DEL XILEMA POR LOS FACTORES DE TRANSCRIPCION AJAX/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Vera Sirera, FJ.; De Rybel, B.; Urbez Lagunas, C.; Kouklas, E.; Pesquera, M.; Álvarez Mahecha, JC.; Minguet, E.... (2015). A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants. Developmental Cell. 35(4):432-443. https://doi.org/10.1016/j.devcel.2015.10.022 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.devcel.2015.10.022 es_ES
dc.description.upvformatpinicio 432 es_ES
dc.description.upvformatpfin 443 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 35 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 306404 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona es_ES
dc.contributor.funder Netherlands Organization for Scientific Research es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Commission


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