- -

Dual functional ionic liquids as antimicrobials and plasticisers for medical grade PVCs

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Dual functional ionic liquids as antimicrobials and plasticisers for medical grade PVCs

Show simple item record

Files in this item

dc.contributor.author Choi, Seong Ying es_ES
dc.contributor.author Rodriguez, Hector es_ES
dc.contributor.author Gunaratne, H. Q. Nimal es_ES
dc.contributor.author Vaca Puga, Alberto es_ES
dc.contributor.author Gilpin, Deirdre es_ES
dc.contributor.author McGrath, Stephanie es_ES
dc.contributor.author Vyle, Joseph S. es_ES
dc.contributor.author Tunney, Michael M. es_ES
dc.contributor.author Rogers, Robin D. es_ES
dc.contributor.author McNally, Tony es_ES
dc.date.accessioned 2016-10-11T12:02:31Z
dc.date.available 2016-10-11T12:02:31Z
dc.date.issued 2014
dc.identifier.issn 2046-2069
dc.identifier.uri http://hdl.handle.net/10251/71622
dc.description.abstract [EN] Two ionic liquids, 1-ethylpyridinium docusate (IL1) and tri-n-butyl(2-hydroxyethyl)phosphonium docusate (IL2), were designed and synthesized with the explicit intention of imparting a combination of plasticization and antimicrobial efficacy when incorporated into medical grade poly(vinyl chloride)s (PVCs). The glass transition (T-g) of PVC can be reduced by >20 degrees C on addition of 15 wt% IL2. Both IL1 and IL2 leached to varying extents from the base PVC resins rendering the surface of the PVCs hydrophilic. The antimicrobial activity of both ILs is related to the presence and concentration of both cationic and anionic component of the ILs leached from the PVC and inversely proportional to the extent of PVC gelation. Blends of the PVCs with IL1 displayed antibacterial activity against almost all Gram-positive bacteria tested, including coagulase-negative Staphylococci (CoNS) and methicillin-resistant Staphylococcus aureus (MRSA), but not with IL2 at low concentration in contrast to our previous study when high concentrations of IL2 were used. The more hydrophilic IL1 when added to PVC retards biofilm formation. es_ES
dc.description.sponsorship S. Y. Choi thanks QUB for funding her studentship. We acknowledge the technical assistance of Gareth Graham, Drs Bronagh Millar, Paula Douglas, Saloni Shukla, Lan Wei, and Colorite Europe Ltd. for supplying the PVC formulations. We thank Dr David Timson (QUB) for helpful discussions.
dc.language Inglés es_ES
dc.publisher Royal Society of Chemistry es_ES
dc.relation.ispartof RSC Advances es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Dual functional ionic liquids as antimicrobials and plasticisers for medical grade PVCs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/C3RA46425C
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Choi, SY.; Rodriguez, H.; Gunaratne, HQN.; Vaca Puga, A.; Gilpin, D.; Mcgrath, S.; Vyle, JS.... (2014). Dual functional ionic liquids as antimicrobials and plasticisers for medical grade PVCs. RSC Advances. 4(17):8567-8581. doi:10.1039/C3RA46425C es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1039/c3ra46425c es_ES
dc.description.upvformatpinicio 8567 es_ES
dc.description.upvformatpfin 8581 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 4 es_ES
dc.description.issue 17 es_ES
dc.relation.senia 280601 es_ES
dc.contributor.funder Queen's University Belfast


This item appears in the following Collection(s)

Show simple item record