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dc.contributor.author | Martínez Ramos, Cristina | es_ES |
dc.contributor.author | Gomez Pinedo, Ulises Alfonso | es_ES |
dc.contributor.author | Garcia Esparza, Mª Ángeles | es_ES |
dc.contributor.author | Soria Lopez, Jose Miguel | es_ES |
dc.contributor.author | Barcia Albacar, Juan Antonio | es_ES |
dc.contributor.author | Monleón Pradas, Manuel | es_ES |
dc.date.accessioned | 2016-10-17T09:04:59Z | |
dc.date.available | 2016-10-17T09:04:59Z | |
dc.date.issued | 2015-06-26 | |
dc.identifier.issn | 0304-3940 | |
dc.identifier.uri | http://hdl.handle.net/10251/71897 | |
dc.description.abstract | The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury. | es_ES |
dc.description.sponsorship | CMR, JAB, UGP, and MMP acknowledge financing through projects MAT2011-28791-C03-01 and MAT2011-28791-C03-02 and ERA-NET NEURON project PRI-PIMNEU-2011-1372. JMSL acknowledges funding through Programa de Ayudas a la Investigacion Cientifica Universidad CEU-Cardenal Herrera (PRCEU-UCH 34/12, PRCEU-UCH 38/10) and Programa CEU-Santader ayudas a grupos consolidados 2014-2015. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Neuroscience Letters | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Scaffold | es_ES |
dc.subject | Brain | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Cryolesion | es_ES |
dc.subject | Tissue engineering | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.neulet.2015.05.021 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//PRI-PIMNEU-2011-1372/ES/MATERIALES BIFUNCIONALES PARA LA REGENERACION NEURAL DE AREAS AFECTADAS POR ICTUS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Universidad CEU Cardenal Herrera//PRCEU-UCH 34%2F12/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Universidad CEU Cardenal Herrera//PRCEU-UCH 38%2F10/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-01/ES/BIOHIBRIDOS DE CELULAS TRONCALES Y MATERIALES PARA AUMENTAR LA SUPERVIVENCIA, INTEGRACION Y REGENERACION AXONAL EN EL SISTEMA NERVIOSO CENTRAL.MODELOS ANIMALES DE EP, ELA E IC/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-02/ES/MATERIALES DE SOPORTE Y LIBERACION CONTROLADA PARA LA REGENERACION DE ESTRUCTURAS NEURALES AFECTADAS POR ICTUS/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular | es_ES |
dc.description.bibliographicCitation | Martínez Ramos, C.; Gomez Pinedo, UA.; Garcia Esparza, MÁ.; Soria Lopez, JM.; Barcia Albacar, JA.; Monleón Pradas, M. (2015). Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers. Neuroscience Letters. 598:96-101. https://doi.org/10.1016/j.neulet.2015.05.021 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.neulet.2015.05.021 | es_ES |
dc.description.upvformatpinicio | 96 | es_ES |
dc.description.upvformatpfin | 101 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 598 | es_ES |
dc.relation.senia | 295663 | es_ES |
dc.identifier.eissn | 1872-7972 | |
dc.contributor.funder | Banco Santander | es_ES |
dc.contributor.funder | Universidad CEU Cardenal Herrera | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Universidad San Pablo - CEU | es_ES |