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Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) as Ex Vivo Platforms for Articular Cartilage Regeneration

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Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) as Ex Vivo Platforms for Articular Cartilage Regeneration

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dc.contributor.author Poveda Reyes, Sara es_ES
dc.contributor.author Gamboa Martínez, Tatiana Carolina es_ES
dc.contributor.author Manzano, Sara es_ES
dc.contributor.author Doweidar, Mohamed Hamdy es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Ochoa Garrido, Ignacio es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.date.accessioned 2016-10-17T09:33:23Z
dc.date.available 2016-10-17T09:33:23Z
dc.date.issued 2015
dc.identifier.issn 0091-4037
dc.identifier.uri http://hdl.handle.net/10251/71903
dc.description.abstract A hydrogel based on interpenetrating polymer networks (IPNs) has been designed to act as a platform in an articular cartilage bioreactor for the ex vivo test of scaffolds, simulating the host tissue. Poly(2-hydroxyethyl acrylate) (PHEA) has been mechanically reinforced by its interpenetration with poly(ethyl acrylate). The resulting IPNs are phase separated systems with a porosity that increases with the amount of PHEA. Compression Young s modulus decreases and permeability increases when increasing the PHEA content in the samples, being the IPN with a 79% of PHEA the best candidate to mimic articular cartilage. es_ES
dc.description.sponsorship The authors gratefully acknowledge the financial support from the Spanish Ministry of Economy and Competitiveness through the MAT2013-46467-C4-1-R and MAT2013-46467-C4-3-R projects (including the FEDER financial support), the FPU AP2010/2557 and the FPI BES-2011-046144 PhD grants, and the CIBER-BBN. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The translation of this paper was funded by the Universitat Politecnica de Valencia, Spain. en_EN
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation.ispartof International Journal of Polymeric Materials and Polymeric Biomaterials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Ex vivo articular cartilage platform es_ES
dc.subject Hydrogels es_ES
dc.subject Interpenetrating polymer networks es_ES
dc.subject Poly(2-hydroxyethyl acrylate) es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) as Ex Vivo Platforms for Articular Cartilage Regeneration es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1080/00914037.2014.1002132
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-3-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//AP2010-2557/ES/AP2010-2557/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BES-2011-046144/ES/BES-2011-046144/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Poveda Reyes, S.; Gamboa Martínez, TC.; Manzano, S.; Doweidar, MH.; Gómez Ribelles, JL.; Ochoa Garrido, I.; Gallego-Ferrer, G. (2015). Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) as Ex Vivo Platforms for Articular Cartilage Regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials. 64(14):745-754. https://doi.org/10.1080/00914037.2014.1002132 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1080/00914037.2014.1002132 es_ES
dc.description.upvformatpinicio 745 es_ES
dc.description.upvformatpfin 754 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 64 es_ES
dc.description.issue 14 es_ES
dc.relation.senia 286531 es_ES
dc.identifier.eissn 1563-535X
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES


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