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dc.contributor.author | Gallach, Sandra | es_ES |
dc.contributor.author | Calabuig-Farinas, Silvia | es_ES |
dc.contributor.author | Jantus Lewintre, Eloisa | es_ES |
dc.contributor.author | Camps, Carlos | es_ES |
dc.date.accessioned | 2016-10-24T07:26:32Z | |
dc.date.available | 2016-10-24T07:26:32Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | http://hdl.handle.net/10251/72641 | |
dc.description.abstract | [EN] MicroRNAs are one class of small, endogenous, non-coding RNAs that are approximately 22 nucleotides in length; they are very numerous, have been phylogenetically conserved, and involved in biological processes such as development, differentiation, cell proliferation, and apoptosis. MicroRNAs contribute to modulating the expression levels of specific proteins based on sequence complementarity with their target mRNA molecules and so they play a key role in both health and disease. Angiogenesis is the process of new blood vessel formation from preexisting ones, which is particularly relevant to cancer and its progression. Over the last few years, microRNAs have emerged as critical regulators of signalling pathways in multiple cell types including endothelial and perivascular cells. This review summarises the role of miRNAs in tumour angiogenesis and their potential implications as therapeutic targets in cancer. | es_ES |
dc.description.sponsorship | This study was partially supported by a Grant from Ministerio de Ciencia e Inovacion de Espana (TRA09-0132), Beca Roche en Onco-Hematologia 2009, and Red Tematica de Investigacion Cooperativa en Cancer (RD12/0036/0025). | |
dc.language | Inglés | es_ES |
dc.publisher | Hindawi Publishing Corporation | es_ES |
dc.relation.ispartof | BioMed Research International | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | es_ES |
dc.subject | HUMAN BREAST-CANCER | es_ES |
dc.subject | TUMOR ANGIOGENESIS | es_ES |
dc.subject | GENE-EXPRESSION | es_ES |
dc.subject | DOWN-REGULATION | es_ES |
dc.subject | MIR-200 FAMILY | es_ES |
dc.subject | NUCLEAR EXPORT | es_ES |
dc.subject | SMALL RNAS | es_ES |
dc.subject | IN-VIVO | es_ES |
dc.subject | MICROPROCESSOR COMPLEX | es_ES |
dc.subject.classification | MICROBIOLOGIA | es_ES |
dc.title | MicroRNAs: Promising New Antiangiogenic Targets in Cancer | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1155/2014/878450 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//TRA2009_0132/ES/Micro ARNs con expresión diferencial en cáncer de pulmón no microcítico: Control sobre la angiogénesis/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0015/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Gallach, S.; Calabuig-Farinas, S.; Jantus Lewintre, E.; Camps, C. (2014). MicroRNAs: Promising New Antiangiogenic Targets in Cancer. BioMed Research International. 2014. https://doi.org/10.1155/2014/878450 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1155/2014/878450 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 2014 | es_ES |
dc.relation.senia | 282058 | es_ES |
dc.identifier.pmid | 25197665 | |
dc.identifier.pmcid | PMC4150436 | en_EN |
dc.contributor.funder | Ministerio de Ciencia e Innovación | |
dc.contributor.funder | Roche | es_ES |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer | |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |