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How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions

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How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions

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dc.contributor.author Ferrian, Selena es_ES
dc.contributor.author Guerrero, Irene es_ES
dc.contributor.author Blas Ferrer, Enrique es_ES
dc.contributor.author García Diego, Fernando Juan es_ES
dc.contributor.author Viana, David es_ES
dc.contributor.author Pascual Amorós, Juan José es_ES
dc.contributor.author Corpa, Juan M. es_ES
dc.date.accessioned 2016-10-26T07:06:11Z
dc.date.available 2016-10-26T07:06:11Z
dc.date.issued 2012-11
dc.identifier.issn 0165-2427
dc.identifier.uri http://hdl.handle.net/10251/72761
dc.description.abstract [EN] The present work characterises how selection for reproduction (by comparing two generations - 16th and 36th - of the V line selected for litter size at weaning) or foundation for reproductive longevity (the LP line) can affect the blood lymphocytes populations of reproductive rabbit does under normal [conventional housing, average daily minimum and maximum temperatures of 14 degrees C and 20 degrees C, respectively] and heat stress conditions [climatic chamber, 25 degrees C and 36 degrees C] from the first to the second parturition. Housing under heat stress conditions significantly reduced the B lymphocytes counts in female rabbits (-34 x 10(6)/L; P < 0.05). The highest lymphocytes population value in blood (total, T CD5(+), CD4(+) and CD8(+)) was noted at the first parturition, while the B lymphocytes count was significantly lower at the second parturition (-61 x 10(6)/L; P < 0.05). Selection for litter size at weaning (V females) reduced the average counts of total and B lymphocytes in blood (-502 and -60 x 10(6)/L, respectively; P < 0.01), mainly because these populations in V36 females continuously lowered from the first to the second parturition under normal housing conditions. Thus, more selected females (V36) at the second parturition showed significantly lower counts in blood for total, T CD5(+) and CD25(+) lymphocytes (-1303, -446 and -33 x 10(6)/L, respectively; P < 0.05). The main differences in blood counts between V36 and V16 females disappeared when housed under heat stress conditions, except for T CD5(+) and CD25(+), which significantly increased (T CD5(+): +428 x 10(6)/L; CD25(+): +41 x 10(6)/L; P < 0.01) in the V16 vs. V36 females on day 10 post-partum. Under normal conditions, no differences between LP and V36 females were found for most lymphocyte populations; only higher counts were noted in CD25(+) (+20 x 10(6)/L; P < 0.05) for LP females. However, the lymphocytes counts [especially total (+1327 x 10(6)/L; P < 0.01) and T CD5(+) (+376 x 10(6)/L; P < 0.10)] of LP females increased under heat vs. normal conditions when lymphocytes populations presented the lowest values (second parturition), while V36 females' counts remained invariable. Positive correlations were found between feed intake (r = +0.51; P < 0.001) and females' perirenal fat thickness (r = +0.40; P < 0.001) with B lymphocytes counts in the blood of primiparous rabbit females in the week 2 of lactation. These results indicate that selection for litter size at weaning might diminish their immune system's response and adaptation capacity, while the foundation for reproductive longevity criteria leads to more robust rabbit females as they present greater modulation under heat stress conditions when the immune system is affected. (c) 2012 Elsevier B.V. All rights reserved. es_ES
dc.description.sponsorship This study has been supported by grants from the CEU-Cardenal Herrera University (Banco Santander/CEU-UCH: Copernicus Program), Generalitat Valenciana (ACOMP/2009/207 and ACOMP/2010/062) and the Comision Interministerial de Ciencia y Tecnologia (AGL2008-00273/GAN, AGL2008-03274/GAN and AGL2011-30170-CO2-02). Grants for Selena Ferrian and Irene Guerrero from Generalitat Valenciana (the Santiago Grisolia programme) and from the Universidad CEU-Cardenal Herrera, respectively, are also gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Veterinary Immunology and Immunopathology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Rabbit es_ES
dc.subject Lymphocyte populations es_ES
dc.subject Heat stress es_ES
dc.subject Genetic origin es_ES
dc.subject Longevity es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification NUTRICION Y BROMATOLOGIA es_ES
dc.title How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.vetimm.2012.08.007
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//ACOMP%2F2009%2F207/ES/IDENTIFICACIÓN DE FACTORES DE PATOGENICIDAD Y CARACTERIZACIÓN INMUNOPATOLÓGICA DE SU EFECTO EN MAMITIS CUNÍCOLAS PROVOCADAS POR Staphylococcus aureus./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2008-03274/ES/MEJORA GENETICA DEL CONEJO DE CARNE: REPRODUCCION, ESTRES Y LONGEVIDAD/ / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//ACOMP%2F2010%2F062/ES/ACOMP%2F2010%2F062/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2008-00273/ES/IDENTIFICACION DE FACTORES DE PATOGENICIDAD Y CARACTERIZACION INMUNOPATOLOGICA DE SU EFECTO EN MAMITIS CUNICOLAS PROVOCADAS POR STAPHYLOCOCCUS AUREUS./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2011-30170-C02-02/ES/ESTUDIO DEL SISTEMA INMUNE DE DIFERENTES LINEAS GENETICAS CUNICOLAS Y SU RESPUESTA FRENTE A DESAFIOS PRODUCTIVOS E INFECCIOSOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Ferrian, S.; Guerrero, I.; Blas Ferrer, E.; García Diego, FJ.; Viana, D.; Pascual Amorós, JJ.; Corpa, JM. (2012). How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions. Veterinary Immunology and Immunopathology. 150(1-2):53-60. doi:10.1016/j.vetimm.2012.08.007 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1016/j.vetimm.2012.08.007 es_ES
dc.description.upvformatpinicio 53 es_ES
dc.description.upvformatpfin 60 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 150 es_ES
dc.description.issue 1-2 es_ES
dc.relation.senia 236145 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Universidad CEU Cardenal Herrera es_ES


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