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The Core/E1 domain of Hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma

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The Core/E1 domain of Hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma

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dc.contributor.author Zhang, Xiaoan es_ES
dc.contributor.author Ryu, Soo Hyung es_ES
dc.contributor.author Xu, Yanjuan es_ES
dc.contributor.author Elbaz, Tamerl es_ES
dc.contributor.author Zekri, Abdel-Rahman N. es_ES
dc.contributor.author Abdelaziz, Ashraf Omar es_ES
dc.contributor.author Abdel-Hamid, Mohamed es_ES
dc.contributor.author Thiers, Valerie es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.contributor.author Fan, Xiaofeng es_ES
dc.contributor.author Di Bisceglie, Adrian M. es_ES
dc.date.accessioned 2016-10-31T12:59:44Z
dc.date.available 2016-10-31T12:59:44Z
dc.date.issued 2011-12
dc.identifier.issn 1386-6532
dc.identifier.uri http://hdl.handle.net/10251/73002
dc.description.abstract [EN] Background: Hepatitis C virus (HCV) infection is a well-documented etiological factor for hepatocellular carcinoma (HCC). As HCV shows remarkable genetic diversity, an interesting and important issue is whether such a high viral genetic diversity plays a role in the incidence of HCC. Prior data on this subject are conflicting. Objectives: Potential association between HCV genetic mutations or strain variability and HCC incidence has been examined through a comparative genetic analysis merely focused on a single HCV subtype (genotype 4a) in a single country (Egypt). Study design: The study focused on three HCV sequence datasets with explicit sampling dates and disease patterns. An overlapping HCV Core/E1 domain from three datasets was used as the target for comparative analysis through genetic and phylogenetic approaches. Results: Based on partial Core/E1 domain (387 bp), genetic and phylogenetic analysis did not identify any HCC-specific viral mutations and strains, respectively. Conclusions: The Core/E1 domain of HCV genotype 4a in Egypt does not contain HCC-specific mutations or strains. Additionally, sequence errors resulting from the polymerase chain reaction, together with a strong evolutionary pressure on HCV in patients with end-stage liver disease, have significant potential to bias data generation and interpretation. (C) 2011 Elsevier B.V. All rights reserved. es_ES
dc.description.sponsorship This work was supported by NIH grants R01 DK80711 (Dr. Xiaofeng Fan), R21 AI076834 (Dr. Adrian M. Di Bisceglie) and USA and Egypt Science and Technology Joint Fund BIO6-002-004 (Dr. Adrian M. Di Bisceglie).
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Journal of Clinical Virology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Hepatitis C virus es_ES
dc.subject Hepatocellular carcinoma es_ES
dc.subject Cirrhosis es_ES
dc.subject RT-PCR es_ES
dc.subject Egypt es_ES
dc.title The Core/E1 domain of Hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jcv.2011.08.022
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01DK80711/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R21AI076834/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/U.S. - Egypt Science and Technology Joint Fund//BIO6-002-004/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Zhang, X.; Ryu, SH.; Xu, Y.; Elbaz, T.; Zekri, AN.; Abdelaziz, AO.; Abdel-Hamid, M.... (2011). The Core/E1 domain of Hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma. Journal of Clinical Virology. 52(4):333-338. https://doi.org/10.1016/j.jcv.2011.08.022 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jcv.2011.08.022 es_ES
dc.description.upvformatpinicio 333 es_ES
dc.description.upvformatpfin 338 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 52 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 218205 es_ES
dc.identifier.pmid 21925935
dc.identifier.pmcid PMC3217131
dc.contributor.funder National Institutes of Health, EEUU
dc.contributor.funder U.S. - Egypt Science and Technology Joint Fund


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