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Mesoporous Silica-Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract

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Mesoporous Silica-Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract

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dc.contributor.author Pérez-Esteve, Édgar es_ES
dc.contributor.author Ruiz Rico, María es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.date.accessioned 2016-11-02T10:45:03Z
dc.date.available 2016-11-02T10:45:03Z
dc.date.issued 2015-11
dc.identifier.issn 0022-1147
dc.identifier.uri http://hdl.handle.net/10251/73084
dc.description JFS Special Issue: 75 Years of Advancing Food Science, and Preparing for the Next 75 es_ES
dc.description.abstract Mesoporous silica particles (MSPs) have attracted increasing interest as supports in the design of controlled delivery materials. Besides their excellent properties as loading supports (that is, large surface area and pore volume), the modification of their external surface with molecular/supramolecular ensembles allows the design of gated MSPs. Delivery systems based on gated MSPs show zero delivery until an adequate stimulus is present and triggers gate opening and the cargo is released. Encapsulation of bioactive molecules in gated MSPs may improve biological stability, facilitate component handling, mask unpleasant sensorial properties, and modulate the bioaccessibility of target molecules along the gastrointestinal tract. These properties make gated MSPs excellent candidates for encapsulating bioactive molecules and their subsequent utilization in the formulation of functional foods. This text highlights the most significant endogenous triggering stimuli that might be applied to design these site-specific delivery systems, as well as the strategies to develop them. Given the novelty of using MSPs in the food sector, the benefits and current potential limitations of employing MSPs in human food have been identified and discussed. es_ES
dc.description.sponsorship Authors gratefully acknowledge the financial support from the Ministerio de Economia y Competitividad (Projects AGL2012-39597-C02-01, AGL2012-39597-C02-02, and MAT2012-38429-C04-01) and the Generalitat Valenciana (project PROME-TEO/2009/016). E.P. and M.R. are grateful to the Ministerio de Ciencia e Innovacion for their grants (AP2008-00620, AP2010-4369). en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Journal of Food Science es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Controlled delivery es_ES
dc.subject Gastrointestinal tract es_ES
dc.subject Molecular gates es_ES
dc.subject Porous silica es_ES
dc.subject Targeted delivery es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title Mesoporous Silica-Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/1750-3841.13095
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2012-39597-C02-02/ES/MICROPORTADORES INTELIGENTES PARA LA LIBERACION CONTROLADA DE SUSTANCIAS DE INTERES ALIMENTARIO./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2012-39597-C02-01/ES/MEJORA DE LA ESTABILIDAD Y CONTROL DE LA VELOCIDAD DE LIBERACION DE BIOMOLECULAS MEDIANTE EL EMPLEO DE MICROCAPSULAS FUNCIONALIZADAS CON PUERTAS MOLECULARES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AP2008-00620/ES/AP2008-00620/ / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//AP2010-4369/ES/AP2010-4369/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//AP2008-00620/ES/AP2008-00620/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Pérez-Esteve, É.; Ruiz Rico, M.; Martínez-Máñez, R.; Barat Baviera, JM. (2015). Mesoporous Silica-Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract. Journal of Food Science. 80(11):E2504-E2516. https://doi.org/10.1111/1750-3841.13095 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1111/1750-3841.13095 es_ES
dc.description.upvformatpinicio E2504 es_ES
dc.description.upvformatpfin E2516 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 80 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 296801 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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