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Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

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Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

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dc.contributor.author Amr, Fares Ibrahim es_ES
dc.contributor.author Vila, Carlos es_ES
dc.contributor.author Blay, Gonzalo es_ES
dc.contributor.author Muñoz Roca, María del Carmen es_ES
dc.contributor.author Pedro, José R. es_ES
dc.date.accessioned 2016-11-04T14:19:40Z
dc.date.available 2016-11-04T14:19:40Z
dc.date.issued 2016-05-19
dc.identifier.issn 1615-4150
dc.identifier.uri http://hdl.handle.net/10251/73326
dc.description.abstract A quinine-derived thiourea catalysed the enantioselective addition of 4-substituted pyrazolones to isatin-derived ketimines, providing a variety of aminooxindole-pyrazolone adducts containing congested vicinal tetrasubstituted stereocentres with excellent outcomes (up to 98% yield, >20:1 dr and 98% ee). es_ES
dc.description.sponsorship Financial support from the MINECO (Gobierno de Espana and FEDER (EU)) (CTQ2013-47949-P) and from Generalitat Valenciana (ISIC2012/001) is gratefully acknowledged. C. V. thanks MINECO for JdC contract. Access to NMR, MS and X-ray facilities from the Servei central de support a la investigacio experimental (SCSIE)-UV is also acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation Ministerio de Economía y Competitividad (MINECO) (Spain) (CTQ2013-47949-P) es_ES
dc.relation FEDER es_ES
dc.relation Generalitat Valenciana (ISIC2012/001) es_ES
dc.relation Ministerio de Economía y Competitividad (MINECO) (Spain) JdC contract es_ES
dc.relation.ispartof Advanced Synthesis and Catalysis es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Asymmetric catalysis es_ES
dc.subject Isatin-derived ketimines es_ES
dc.subject Organocatalysis es_ES
dc.subject Pyrazolones es_ES
dc.subject Quaternary stereocenters es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/adsc.201600036
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Amr, FI.; Vila, C.; Blay, G.; Muñoz Roca, MDC.; Pedro, JR. (2016). Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters. Advanced Synthesis and Catalysis. 358(10):1583-1588. doi:10.1002/adsc.201600036 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/adsc.201600036 es_ES
dc.description.upvformatpinicio 1583 es_ES
dc.description.upvformatpfin 1588 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 358 es_ES
dc.description.issue 10 es_ES
dc.relation.senia 316156 es_ES
dc.identifier.eissn 1615-4169


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