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Development of Bioactive Patch for Maintenance of Implanted Cells at the Myocardial Infarcted Site

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Development of Bioactive Patch for Maintenance of Implanted Cells at the Myocardial Infarcted Site

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dc.contributor.author Castells-Sala, C. es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Soler-Botija, C. es_ES
dc.contributor.author Arnal Pastor, María Pilar es_ES
dc.contributor.author Martínez Ramos, Cristina es_ES
dc.contributor.author Fernandez-Muinos, T. es_ES
dc.contributor.author Mari-Buye, N. es_ES
dc.contributor.author Llucia-Valldeperas, A. es_ES
dc.contributor.author Sanchez, B. es_ES
dc.contributor.author Chachques, J. C. es_ES
dc.contributor.author Bayes-Genis, A. es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Semino, C. E. es_ES
dc.date.accessioned 2016-11-11T13:07:45Z
dc.date.available 2016-11-11T13:07:45Z
dc.date.issued 2015
dc.identifier.issn 1687-4110
dc.identifier.uri http://hdl.handle.net/10251/73853
dc.description.abstract [EN] Ischemia produced as a result of myocardial infarction might cause moderate or severe tissue death. Studies under development propose grafting stem cells into the affected area and we hypothesize that this mechanism could be enhanced by the application of a "bioactive implant." The implant herein proposed consists of a thin porous elastomeric membrane, filled with self-assembling nanofibers and human subcutaneous adipose tissue derived progenitor cells. We describe the development and characterization of two elastomeric membranes: poly(ethyl acrylate) (PEA) and poly(caprolactone 2-(methacryloyloxy) ethyl ester) (PCLMA). Both are a good material support to deliver cells within a soft self-assembling peptide and are elastic enough to withstand the stresses arising from the heartbeat. Both developed composites (PEA and PCLMA, combined with self-assembling peptide) equally facilitate the propagation of electrical pulses and maintain their genetic profile of the seeded cells. Preliminary studies with small animal models suggest that, at short times, the bioimplant shows good adhesion with the myocardium. After three days cells loaded in the patch remain alive at the implanted site. We propose that the bioactive patch (elastomeric membranes with self-assembling peptide and cells) could increase the efficacy of future cardiac cell therapy by improving cell immobilization and survival at the affected site. es_ES
dc.description.sponsorship The authors wish to thank the Department of Cardiac Surgery (Hospital Germans Trias i Pujol, Badalona) for their collaboration in obtaining human samples, Dr. Bago for his kind contribution in the cell transduction process and BLI analysis, and Joan Gilabert from Biomaterials Laboratory (GEMAT, IQS-School of Engineering) who kindly helped them with wettability measurements. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under Grant agreement no. 229239. This work was also supported by Grants from Ministerio de Educacion y Ciencia (SAF2011-30067-C02-01 and M. Arnal-Pastor FPU 2009-1870 grant), Red de Terapia Celular-TerCel (RD12/0019/0029), Red Cardio-vascular (RD12/0042/0047), and Fundacio La Marato de TV3 (122232). en_EN
dc.language Inglés es_ES
dc.publisher Hindawi Publishing Corporation es_ES
dc.relation MEC/SAF2011-30067-C02-01 es_ES
dc.relation MEC/FPU 2009-1870 es_ES
dc.relation TerCel/RD12/0019/0029 es_ES
dc.relation RIC/RD12/0042/0047 es_ES
dc.relation Fundacio La Marato de TV3/122232 es_ES
dc.relation.ispartof Journal of Nanomaterials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification TERMODINAMICA APLICADA (UPV) es_ES
dc.title Development of Bioactive Patch for Maintenance of Implanted Cells at the Myocardial Infarcted Site es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1155/2015/804017
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/229239/EU
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Castells-Sala, C.; Vallés Lluch, A.; Soler-Botija, C.; Arnal Pastor, MP.; Martínez Ramos, C.; Fernandez-Muinos, T.; Mari-Buye, N.... (2015). Development of Bioactive Patch for Maintenance of Implanted Cells at the Myocardial Infarcted Site. Journal of Nanomaterials. (804017). https://doi.org/10.1155/2015/804017 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1155/2015/804017 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.issue 804017 es_ES
dc.relation.senia 295667 es_ES
dc.contributor.funder Ministerio de Educación y Ciencia
dc.contributor.funder Red de Terapia Celular
dc.contributor.funder Red Cardio-vascular
dc.contributor.funder Fundació La Marató de TV3
dc.contributor.funder European Commission


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