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In vitro development of bioimplants made up of elastomeric scaffolds with peptide gel filling seeded with human subcutaneous adipose tissue-derived progenitor cells

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In vitro development of bioimplants made up of elastomeric scaffolds with peptide gel filling seeded with human subcutaneous adipose tissue-derived progenitor cells

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dc.contributor.author Castells-Sala, Cristina es_ES
dc.contributor.author Martínez Ramos, Cristina es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Semino, Carlos es_ES
dc.date.accessioned 2016-11-16T10:42:18Z
dc.date.available 2016-11-16T10:42:18Z
dc.date.issued 2015-11
dc.identifier.issn 1549-3296
dc.identifier.uri http://hdl.handle.net/10251/74183
dc.description.abstract [EN] Myocardial tissue lacks the ability to regenerate itself significantly following a myocardial infarction. Thus, new strategies that could compensate this lack are of high interest. Cardiac tissue engineering (CTE) strategies are a relatively new approach that aims to compensate the tissue loss using combination of biomaterials, cells and bioactive molecules. The goal of the present study was to evaluate cell survival and growth, seeding capacity and cellular phenotype maintenance of subcutaneous adipose tissue-derived progenitor cells in a new synthetic biomaterial scaffold platform. Specifically, here we tested the effect of the RAD16-I peptide gel in microporous poly(ethyl acrylate) polymers using two-dimensional PEA films as controls. Results showed optimal cell adhesion efficiency and growth in the polymers coated with the self-assembling peptide RAD16-I. Importantly, subATDPCs seeded into microporous PEA scaffolds coated with RAD16-I maintained its phenotype and were able to migrate outwards the bioactive patch, hopefully toward the infarcted area once implanted. These data suggest that this bioimplant (scaffold/RAD16-I/cells) can be suitable for further in vivo implantation with the aim to improve the function of affected tissue after myocardial infarction. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3419-3430, 2015. es_ES
dc.description.sponsorship Contract grant sponsor: European Union Seventh Framework Programme; contract grant number: 229239 en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Journal of Biomedical Materials Research Part A es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title In vitro development of bioimplants made up of elastomeric scaffolds with peptide gel filling seeded with human subcutaneous adipose tissue-derived progenitor cells es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbm.a.35482
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/229239/EU/Regeneration of Cardiac Tissue Assisted by Bioactive Implants/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Castells-Sala, C.; Martínez Ramos, C.; Vallés Lluch, A.; Monleón Pradas, M.; Semino, C. (2015). In vitro development of bioimplants made up of elastomeric scaffolds with peptide gel filling seeded with human subcutaneous adipose tissue-derived progenitor cells. Journal of Biomedical Materials Research Part A. 103(11):3419-3430. https://doi.org/10.1002/jbm.a.35482 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/jbm.a.35482 es_ES
dc.description.upvformatpinicio 3419 es_ES
dc.description.upvformatpfin 3430 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 103 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 295665 es_ES
dc.contributor.funder European Commission
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