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Strain Variation in Mycobacterium avium: polymorphism of IS1110-related sequences

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Strain Variation in Mycobacterium avium: polymorphism of IS1110-related sequences

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dc.contributor.author Hernández Pérez, Manuel es_ES
dc.contributor.author Kunze, Zubair M. es_ES
dc.contributor.author Brown, Sheldon es_ES
dc.contributor.author Yakrus, Mitchell A. es_ES
dc.contributor.author McFadden, Johnjoe es_ES
dc.contributor.author Dale, Jeremy W. es_ES
dc.date.accessioned 2016-11-23T10:49:12Z
dc.date.available 2016-11-23T10:49:12Z
dc.date.issued 1997-04
dc.identifier.issn 1201-9712
dc.identifier.uri http://hdl.handle.net/10251/74516
dc.description.abstract [EN] Objectives: To determine the occurrence and distribution of IS1110 in a sample of clinical isolates; to investigate the polymorphism detected with IS1110-derived probes, and the stability of such patterns; and to evaluate IS1110-based probes, in comparison with other methods, for differentiation of Mycobacterium avium isolates. Design: Fifty M. avium complex strains used for evaluation of the IS1110 probe originated from the Memorial Sloan-Kettering Cancer Center, New York. Results: IS1110 hybridizes to a highly polymorphic element in most M. avium strains. Most banding patterns were found to be unique, but four groups of identical strains were identified. One group, from non-AIDS subjects, was associated with colonization rather than dissemination or invasion. Combining pMB22 and IS1110 typing yielded higher discrimination than either probe alone. Comparison of IS1110 and pMB22 polymorphisms with multilocus enzyme electrophoresis indicated that the three methods were essentially independent. Conclusions: IS1110 provides a convenient method for differentiating M. avium isolates for epidemiologic purposes. es_ES
dc.description.sponsorship Supported by the Commission of the European Communities under the following programs: International Scientific Cooperation (contract number CIl-CT91-0905), Science and Technology for Development (contract number TS2-0080~UK), and Biomedicine and Health Research (Concerted Action on the Epidemiology of Tuberculosis: contract num ber BMHI-CT93-1514).
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation EU/CII-CT91-0905
dc.relation EU/TS2-0080-UK
dc.relation EU/BMHI-CT93-1514
dc.relation.ispartof International Journal of Infectious Diseases es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject AIDS es_ES
dc.subject Epidemiology es_ES
dc.subject Insertion sequence es_ES
dc.subject Mycobacterium avium es_ES
dc.subject Polymorphism es_ES
dc.subject Typing es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.title Strain Variation in Mycobacterium avium: polymorphism of IS1110-related sequences es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/S1201-9712(97)90035-7
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Hernández Pérez, M.; Kunze, ZM.; Brown, S.; Yakrus, MA.; Mcfadden, J.; Dale, JW. (1997). Strain Variation in Mycobacterium avium: polymorphism of IS1110-related sequences. International Journal of Infectious Diseases. 1(4):212-219. doi:10.1016/S1201-9712(97)90035-7 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1016/S1201-9712(97)90035-7 es_ES
dc.description.upvformatpinicio 212 es_ES
dc.description.upvformatpfin 219 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 1 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 26850 es_ES
dc.contributor.funder European Commission


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