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The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity

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The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity

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dc.contributor.author Zarzoso Muñoz, Manuel es_ES
dc.contributor.author Such Miquel, Luis es_ES
dc.contributor.author Parra Giraldo, Germán es_ES
dc.contributor.author Brines Ferrando, Laia es_ES
dc.contributor.author Such, L. es_ES
dc.contributor.author Chorro, F.J. es_ES
dc.contributor.author Guerrero, Juan es_ES
dc.contributor.author Guill Ibáñez, Antonio es_ES
dc.contributor.author O'Connor, J.E. es_ES
dc.contributor.author Alberola, A. es_ES
dc.date.accessioned 2016-11-24T16:36:34Z
dc.date.available 2016-11-24T16:36:34Z
dc.date.issued 2012-06
dc.identifier.issn 1439-6319
dc.identifier.uri http://hdl.handle.net/10251/74587
dc.description.abstract The purpose of this study is to test the role that parasympathetic postganglionic neurons could play on the adaptive electrophysiological changes produced by physical training on intrinsic myocardial automatism, conduction and refractoriness. Trained rabbits were submitted to aphysical training protocol on treadmill during 6 weeks. The electrophysiological study was performed in an isolated heart preparation. The investigated myocardial properties were: (a) sinus automatism, (b) atrioventricular and ventriculoatrial conduction, (c) atrial, conduction system and ventricular refractoriness. The parameters to study the refractoriness were obtained by means of extrastimulus test at four diVerent pacing cycle lengths (10% shorter than spontaneous sinus cycle length, 250, 200 and 150 ms) and (d) mean dominant frequency (DF) of the induced ventricular Wbrillation (VF), using a spectral method. The electrophysiological protocol was performed before and during continuous atropine administration (1 ¿M), in order to block cholinergic receptors. Cholinergic receptor blockade did not modify either the increase in sinus cycle length, atrioventricular conduction and refractoriness (left ventricular and atrioventricular conduction system functional refractory periods) or the decrease of DF of VF. These Wndings reveal that the myocardial electrophysiological modiWcations produced by physical training are not mediated by intrinsic cardiac parasympathetic activity. es_ES
dc.description.sponsorship The authors thank Carmen Rams, Ana Diaz, Pilar Navarro and Cesar Avellaneda for their excellent technical assistance. This work has been supported by grants from the Spanish Ministry of Education and Science (DEP2007-73234-C03-01) and Generalitat Valenciana (PROMETEO 2010/093). M Zarzoso was supported by a research scholarship from Generalitat Valenciana (BFPI/2008/003). en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof European Journal of Applied Physiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Physical training es_ES
dc.subject Parasympatheticpostganglionic neurons es_ES
dc.subject Heart electrophysiology es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00421-011-2189-4
dc.relation.projectID info:eu-repo/grantAgreement/MEC//DEP2007-73234-C03-01/ES/MODIFICACIONES ELECTROFISIOLOGICAS PRODUCIDAS POR EL EJERCICIO FISICO CRONICO: INFLUENCIA DEL SISTEMA NERVIOSO CARDIACO Y DEL ESTRES OXIDATIVO MITOCONDRIAL./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F093/ES/Análisis de los efectos de las modificaciones electrofisiológicas sobre los procesos fibrilatorios/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//BFPI%2F2008%2F003/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Zarzoso Muñoz, M.; Such Miquel, L.; Parra Giraldo, G.; Brines Ferrando, L.; Such, L.; Chorro, F.; Guerrero, J.... (2012). The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity. European Journal of Applied Physiology. 112(6):2185-2193. https://doi.org/10.1007/s00421-011-2189-4 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s00421-011-2189-4 es_ES
dc.description.upvformatpinicio 2185 es_ES
dc.description.upvformatpfin 2193 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 112 es_ES
dc.description.issue 6 es_ES
dc.relation.senia 236615 es_ES
dc.contributor.funder Ministerio de Educación y Ciencia es_ES
dc.contributor.funder Generalitat Valenciana es_ES
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