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Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus

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Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus

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dc.contributor.author López Gresa, Mª Pilar es_ES
dc.contributor.author Cabedo Escrig, Nuria es_ES
dc.contributor.author Gonzalez-Mas, M. Carmen es_ES
dc.contributor.author Ciavatta, Maria Letizia es_ES
dc.contributor.author Avila, Conxita es_ES
dc.contributor.author Primo Millo, Jaime es_ES
dc.date.accessioned 2016-11-30T11:35:46Z
dc.date.issued 2009-07
dc.identifier.issn 0163-3864
dc.identifier.uri http://hdl.handle.net/10251/74800
dc.description Supporting Information Available: 1D and 2D NMR spectra for terretonins E and F. This material is available free of charge via the Internet at http://pubs.acs.org. es_ES
dc.description.abstract [EN] Two new meroterpenoids, terretonins E and F (1, 2), together with three known compounds, aurantiamine (3), linoleic acid, and uridine, were isolated as fermentation products of the marine-derived fungus Aspergillus insuetus, which was associated with the sponge Petrosia ficiformis. Structures of all isolates were elucidated employing spectroscopic methods, mainly by two-dimensional NMR techniques. Compounds 1-3 showed activity as inhibitors of the mammalian mitochondrial respiratory chain. es_ES
dc.description.sponsorship We acknowledge ICB and ITQ NMR Service (D. Melck and E. Mateos) and E. Estornell and V. Romero for biological assay support. We would like to thank the R&D&I Linguistic Assistance Office, Universidad Politecnica de Valencia (Spain), for granting financial support for the linguistic revision of this paper. This work has been supported through European Social Fund (ESF). en_EN
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Journal of Natural Products es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject COMPLEX-I es_ES
dc.subject ABSOLUTE-CONFIGURATIONS es_ES
dc.subject MOSHER METHOD es_ES
dc.subject STRAIN es_ES
dc.subject ACETOGENINS es_ES
dc.subject DERIVATIVES es_ES
dc.subject CITREOHYBRIDONES es_ES
dc.subject INSECTICIDES es_ES
dc.subject METABOLITES es_ES
dc.subject DITERPENES es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1021/np900085n
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation López Gresa, MP.; Cabedo Escrig, N.; Gonzalez-Mas, MC.; Ciavatta, ML.; Avila, C.; Primo Millo, J. (2009). Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus. Journal of Natural Products. 72(7):1348-1351. doi:10.1021/np900085n es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1021/np900085n es_ES
dc.description.upvformatpinicio 1348 es_ES
dc.description.upvformatpfin 1351 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 72 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 36618 es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder European Social Fund es_ES


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