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Time evolution of in vivo articular cartilage repair induced by bone marrow stimulation and scaffold implantation in rabbits

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Time evolution of in vivo articular cartilage repair induced by bone marrow stimulation and scaffold implantation in rabbits

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dc.contributor.author Sancho-Tello Valls, Maria es_ES
dc.contributor.author Forriol, Francisco es_ES
dc.contributor.author Gastaldi, Pablo es_ES
dc.contributor.author Ruiz Sauri, Amparo es_ES
dc.contributor.author Martín de Llano, Jose Javier es_ES
dc.contributor.author Novella-Maestre, E. es_ES
dc.contributor.author Antolinos Turpín, Carmen María es_ES
dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Carda, Carmen es_ES
dc.date.accessioned 2016-12-01T12:53:21Z
dc.date.available 2016-12-01T12:53:21Z
dc.date.issued 2015-04
dc.identifier.issn 0391-3988
dc.identifier.uri http://hdl.handle.net/10251/74865
dc.description.abstract Purpose: Tissue engineering techniques were used to study cartilage repair over a 12-month period in a rabbit model. Methods: A full-depth chondral defect along with subchondral bone injury were originated in the knee joint, where a biostable porous scaffold was implanted, synthesized of poly(ethyl acrylate-co-hydroxyethyl acrylate) copolymer. Morphological evolution of cartilage repair was studied 1 and 2 weeks, and 1, 3, and 12 months after implantation by histological techniques. The 3-month group was chosen to compare cartilage repair to an additional group where scaffolds were preseeded with allogeneic chondrocytes before implantation, and also to controls, who underwent the same surgery procedure, with no scaffold implantation. Results: Neotissue growth was first observed in the deepest scaffold pores 1 week after implantation, which spread thereafter; 3 months later scaffold pores were filled mostly with cartilaginous tissue in superficial and middle zones, and with bone tissue adjacent to subchondral bone. Simultaneously, native chondrocytes at the edges of the defect started to proliferate 1 week after implantation; within a month those edges had grown centripetally and seemed to embed the scaffold, and after 3 months, hyaline-like cartilage was observed on the condylar surface. Preseeded scaffolds slightly improved tissue growth, although the quality of repair tissue was similar to non-preseeded scaffolds. Controls showed that fibrous cartilage was mainly filling the repair area 3 months after surgery. In the 12-month group, articular cartilage resembled the untreated surface. Conclusions: Scaffolds guided cartilaginous tissue growth in vivo, suggesting their importance in stress transmission to the cells for cartilage repair. es_ES
dc.description.sponsorship This study was supported by the Spanish Ministry of Science and Innovation through MAT2010-21611-C03-00 project (including the FEDER financial support), by Conselleria de Educacion (Generalitat Valenciana, Spain) PROMETEO/2011/084 grant, and by CIBER-BBN en Bioingenieria, Biomateriales y Nanomedicina. The work of JLGR was partially supported by funds from the Generalitat Valenciana, ACOMP/2012/075 project. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the - Instituto de Salud Carlos III with assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Wichtig es_ES
dc.relation.ispartof International Journal of Artificial Organs es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cartilage es_ES
dc.subject Regenerative medicine es_ES
dc.subject Biocompatible materials es_ES
dc.subject Tissue scaffolds es_ES
dc.subject Experimental animal models es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Time evolution of in vivo articular cartilage repair induced by bone marrow stimulation and scaffold implantation in rabbits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.5301/ijao.5000404
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2010-21611-C03-01/ES/MATERIALES BIOESTABLES Y BIOREABSORBIBLES A LARGO PLAZO COMO SOPORTES MACROPOROSOS PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2011%2F084/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACOMP%2F2012%2F075/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Sancho-Tello Valls, M.; Forriol, F.; Gastaldi, P.; Ruiz Sauri, A.; Martín De Llano, JJ.; Novella-Maestre, E.; Antolinos Turpín, CM.... (2015). Time evolution of in vivo articular cartilage repair induced by bone marrow stimulation and scaffold implantation in rabbits. International Journal of Artificial Organs. 38(4):210-223. https://doi.org/10.5301/ijao.5000404 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.5301/ijao.5000404 es_ES
dc.description.upvformatpinicio 210 es_ES
dc.description.upvformatpfin 223 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 38 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 289633 es_ES
dc.identifier.eissn 1724-6040
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
dc.contributor.funder European Regional Development Fund es_ES
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