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Ultra-deep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants

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Ultra-deep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants

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Martínez García, F.; Lafforgue, G.; Morelli, M.; González-Candelas, F.; Chua, N.; Daros Arnau, JA.; Elena Fito, SF. (2012). Ultra-deep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants. Molecular Biology and Evolution. 29(11):3297-3307. doi:10.1093/molbev/mss135

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Title: Ultra-deep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants
Author: Martinez Garcia, Fernando Lafforgue, Guillaume Morelli, M. González-Candelas, F. CHUA, N.H. Daros Arnau, Jose Antonio Elena Fito, Santiago Fco
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Issued date:
Abstract:
[EN] Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance ...[+]
Subjects: Artificial micro-RNAs , Experimental evolution , Next-generation sequencing , Population genetics , Resistant plants , Virus evolution
Copyrigths: Reserva de todos los derechos
Source:
Molecular Biology and Evolution. (issn: 0737-4038 )
DOI: 10.1093/molbev/mss135
Publisher:
Oxford University Press (OUP)
Publisher version: https://dx.doi.org/10.1093/molbev/mss135
Project ID:
Human Frontier Science Program Organization [RGP0012/2008]
...[+]
Human Frontier Science Program Organization [RGP0012/2008]
Generalitat Valenciana [PROMETEO/2010/019]
CSIC [2010TW0015]
Universidad Politecnica de Valencia
SYSBIO from the UK BBSRC [BB/F005733/1]
BFU2011-24112
BIO2008-01986
BIO2011-26741
Ministerio de Ciencia e Innovacion BFU2009-06993
[-]
Thanks:
The authors thank Francisca de la Iglesia for technical assistance and the useful comments from two anonymous reviewers. This research was supported by the Human Frontier Science Program Organization grant RGP0012/2008, ...[+]
Type: Artículo

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