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Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds

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Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds

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dc.contributor.author Rogina, Anamarija es_ES
dc.contributor.author Rico Tortosa, Patricia María es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Ivankovic, Marica es_ES
dc.contributor.author Ivankovic, Hrvoje es_ES
dc.date.accessioned 2016-12-20T09:44:14Z
dc.date.available 2016-12-20T09:44:14Z
dc.date.issued 2015-07
dc.identifier.issn 0014-3057
dc.identifier.uri http://hdl.handle.net/10251/75422
dc.description.abstract New in situ highly-porous chitosan/hydroxyapatite (CS/HA) biocomposite scaffolds have been prepared via freeze-gelation technique. Different content of in situ synthesized hydroxyapatite within chitosan solution was obtained by changing the amount of calcium and phosphate precursors. The composition of precipitated inorganic phase was characterized by X-ray diffraction analysis (XRD) and Fourier transformed infrared spectroscopy (FTIR), while morphology of scaffolds was imaged by scanning electron microscopy (SEM). SEM observations of cross section and surface area of prepared scaffolds have shown different microstructure and topography regarding to the HA content, which plays an important role in cell adhesion and proliferation, and nutrient transport. The MIT assay of scaffolds with different content of hydroxyapatite has shown no toxicity which is one of the main requirements for potential biomedical application. Likewise, the presented synthesis allows preparing the scaffolds with large and very well interconnected pores without obtaining toxic intermediate products. es_ES
dc.description.sponsorship CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof European Polymer Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Chitosan (CS) es_ES
dc.subject In situ hydoxyapatite (HA) es_ES
dc.subject Freeze-gelation es_ES
dc.subject Highly-porous structure es_ES
dc.subject Cytotoxicity es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.eurpolymj.2015.05.004
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MZOS//125-1252970-3005/HR/Bioceramic, Polymer and Composite Nanostructured Materials/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Rogina, A.; Rico Tortosa, PM.; Gallego-Ferrer, G.; Ivankovic, M.; Ivankovic, H. (2015). Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds. European Polymer Journal. 68:278-287. https://doi.org/10.1016/j.eurpolymj.2015.05.004 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.eurpolymj.2015.05.004 es_ES
dc.description.upvformatpinicio 278 es_ES
dc.description.upvformatpfin 287 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 68 es_ES
dc.relation.senia 301013 es_ES
dc.identifier.eissn 1873-1945
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder L'Oréal es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Ministry of Science, Education and Sports, Croacia


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