Mostrar el registro sencillo del ítem
dc.contributor.author | Hernandez-Gil, Javier | es_ES |
dc.contributor.author | Ferrer, Sacramento | es_ES |
dc.contributor.author | Cabedo Escrig, Nuria | es_ES |
dc.contributor.author | López Gresa, Mª Pilar | es_ES |
dc.contributor.author | Castineiras, Alfonso | es_ES |
dc.contributor.author | Lloret, Francesc | es_ES |
dc.date.accessioned | 2016-12-20T13:15:10Z | |
dc.date.available | 2016-12-20T13:15:10Z | |
dc.date.issued | 2013-08 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.uri | http://hdl.handle.net/10251/75467 | |
dc.description.abstract | [EN] Two novel naphthalene-sulfonyl-triazole ligands, 5-amino-N1-(naphthalen-3-ylsulfony1)-1,2,4-triazole (anstrz) and 3,5-diamino-N1-(naphthalen-3-ylsulfony1)-1,2,4-triazole (danstrz), purposely designed to interact with DNA, have been prepared for the first time and then fully characterized by H-1, C-13 NMR and IR spectroscopy, mass spectrometry and elemental analysis. The crystal structures of two copper complexes of these derivatives, i.e. [Cu(anstrz)(4)(NO3)(2)]center dot 4CH(3)OH (1), mononuclear, and [Cu(danstrz)(mu-OAc)(2)](2)center dot 2(danstrz) (OAc = acetato) (2), dinuclear, have been determined by single-crystal X-ray diffraction. In both cases the ligand coordinates in a monodentate fashion via the N4 nitrogen atom of the triazole ring. Compound 2, an example of paddle wheel type copper acetate, presents a Cu - Cu' distance of 2.667(1) angstrom. As a result of strong stacking interactions and intense H-bonds, the structure of 2 constitutes a MOF (metal-organic framework). Besides, this dinuclear compound exhibits a very strong antiferromagnetic coupling (J = -324 cm(-1)) and a silent X-band EPR at room temperature. The affinity toward DNA of 1 and 2 has been examined by fluorescence emission spectroscopy, thermal denaturation and viscosimetry assays. The apparent binding constant (K-app) values of 2.2 x 10(7) M-1 for 1 and 2.6 x 10(7) M-1 for 2 suggest important DNA interaction. The dinuclear compound (2) intercalates and produces a high change in the T-m. Both compounds promote DNA scission in the presence of H2O2/ascorbate (1) or ascorbate (2) through oxidative mechanism. The possible reasons for the higher DNA affinity and the more efficient DNA cleavage displayed by compound 2 in relation to compound 1 are discussed. | es_ES |
dc.description.sponsorship | This work was supported by the Ministerio de Educacion y Ciencia (MEC, Spain) (Project CTQ2007-63690/BQU), and by the Ministerio de Ciencia e Innovacion and FEDER-EC (Project MAT2010-15594). JHG acknowledges for a PhD. grantship (Project CTQ2007-63690/BQU, MEC, Spain). | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Journal of Inorganic Biochemistry | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | 1,2,4-Triazole ligands | es_ES |
dc.subject | Cu(II)-triazole complexes | es_ES |
dc.subject | Paddle wheel type copper acetate compound | es_ES |
dc.subject | DNA interaction | es_ES |
dc.subject | Nuclease activity | es_ES |
dc.subject.classification | BIOQUIMICA Y BIOLOGIA MOLECULAR | es_ES |
dc.title | Two copper complexes from two novel naphthalene-sulfonyl-triazole ligands: Different nuclearity and different DNA binding and cleavage capabilities | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.jinorgbio.2013.04.007 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//CTQ2007-63690/ES/COMPUESTOS DE COORDINACION BIOLOGICAMENTE ACTIVOS: MIMETICOS DE LA ENZIMA SUPEROXIDO-DISMUTASA (SOD), NUCLEASAS QUIMICAS ARTIFICIALES Y ANTIBACTERIANOS./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//MAT2010-15594/ES/MATERIALES CRISTALINOS MICROPOROSOS BASADOS EN POLIMEROS DE COORDINACION DE LOS LANTANIDOS CON CARBOXILATOS. SINTESIS, PROPIEDADES Y APLICACIONES POTENCIALES/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia | es_ES |
dc.description.bibliographicCitation | Hernandez-Gil, J.; Ferrer, S.; Cabedo Escrig, N.; López Gresa, MP.; Castineiras, A.; Lloret, F. (2013). Two copper complexes from two novel naphthalene-sulfonyl-triazole ligands: Different nuclearity and different DNA binding and cleavage capabilities. Journal of Inorganic Biochemistry. 125:50-63. https://doi.org/10.1016/j.jinorgbio.2013.04.007 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1016/j.jinorgbio.2013.04.007 | es_ES |
dc.description.upvformatpinicio | 50 | es_ES |
dc.description.upvformatpfin | 63 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 125 | es_ES |
dc.relation.senia | 253927 | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |